Chp2 anticorps

N° du produit ABIN6940567

Détail du produit anti-Chp2 anticorps

Antigène: Chp2

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Chp2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Purification: Purified by Protein A/G

Immunogène: Recombinant human full-length CHP2 protein

Clone: CPTC-CHP2-1

Isotype: IgG2c kappa

Information d'application

Indications d'application:

Positive Control: MCF-7, PC-3, HT29, K562 or Jurkat cell lysates. Human appendix or testis.

Known Application: Western Blot (1-2 μg/mL), Immunofluorescence (1-2 μg/mL),Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Chp2

Antigène: Chp2

Abstract: Chp2 Produits

Synonymes: anticorps 2010110P09Rik, anticorps Cbhp2, anticorps chp-2, anticorps calcineurin-like EF hand protein 2, anticorps calcineurin like EF-hand protein 2, anticorps Chp2, anticorps CHP2

Sujet: CHP2 (calcineurin B homologous protein 2), also known as hepatocellular carcinoma-associated antigen 520, is a 196 amino acid protein that contains 4 EF-hand domains and plays a potential role in transmembrane Na+/H+ exchange. By binding to and activating NHE-1, CHP2 increases the pH and works to protect cells from serum deprivation-induced death. Though not typically detected in normal tissues, CHP2 is highly expressed in malignantly transformed cells and is therefore considered to be a tumor-associated antigen. Ectopic expression of CHP2 promotes proliferation of HEK293 cells and knockdown of CHP2 mRNA in HepG2 cells inhibits cell proliferation. Like calcineurin B, CHP2 can bind to and stimulate phosphatase activity of calcineurin A and activate the calcineurin/NFAT signaling pathway.

Poids moléculaire: 22kDa

ID gène: 63928

UniProt: O43745