SREBF2 anticorps

N° du produit ABIN6940660

Détail du produit anti-SREBF2 anticorps

Antigène: SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SREBF2 est non-conjugé

Application: ELISA, Coating (Coat)

Purification: Purified by Protein A/G

Immunogène: Recombinant full-length human SREBF2 protein

Clone: SREBP2-1579

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Positive Control: Ubiqutious expression in adult and fetal tissues. Hep2 or HeLa cells.

Known Application: ELISA (For coating, order antibody without BSA), Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur SREBF2

Antigène: SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))

Autre désignation: SREBF2 (SREBF2 Produits)

Synonymes: anticorps SREBF2, anticorps srebp2, anticorps SREBP2, anticorps zgc:158371, anticorps AI608257, anticorps SREBP-2, anticorps SREBP2gc, anticorps bHLHd2, anticorps lop13, anticorps nuc, anticorps Srebf2_retired, anticorps sterol regulatory element binding transcription factor 2, anticorps sterol regulatory element binding factor 2, anticorps sterol regulatory element binding transcription factor 2 L homeolog, anticorps SREBF2, anticorps srebf2, anticorps Srebf2, anticorps srebf2.L

Sujet: The low density lipoprotein (LDL) receptor mediates the endocytic uptake of cholesterol-carrying lipoproteins, thereby controlling cholesterol levels in cells and plasma. Transcription of the LDL receptor gene is controlled by a ten base pair sequence in the 5' flanking region, designated sterol regulatory element 1 (SRE-1). When cellular sterol stores are depleted, the element is activated, the gene is transcribed and the cellular uptake of LDL increases. A set of SREbinding proteins (SREBPs) have been identified, including two basic helixloop-helix-leucine zipper (bHLH-zip) transcription factors, designated SREBP-1 and SREBP-2. SREBP-1 and SREBP-2 have been shown to have the same specificity for SRE-1 in vitro and to activate the transcription of reporter genes containing SRE-1 in the same way.

Poids moléculaire: 68/125kDa

ID gène: 6721

UniProt: Q12772

Pathways: Regulation of Lipid Metabolism by PPARalpha