BRCA1 anticorps (AA 445-620)
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- Antigène Voir toutes BRCA1 Anticorps
- BRCA1 (Breast Cancer 1 (BRCA1))
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Épitope
- AA 445-620
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp BRCA1 est non-conjugé
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Application
- Immunohistochemistry (IHC), Immunostaining (ISt), Staining Methods (StM)
- Purification
- Purified by Protein A/G
- Immunogène
- Recombinant human BRCA1 protein fragment (around aa445-620) (exact sequence is proprietary)
- Clone
- BRCA1-1398
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product BRCA1 Anticorps primaire
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- Indications d'application
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Positive Control: A431 or HeLa cells. Breast, Ovarian or Renal Cell Carcinoma.
Known Application: Immunohistochemistry (Formalin-fixed) (2-5 μg/mL for 60 minutes at RT)(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
- Restrictions
- For Research Use only
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- Concentration
- 200 μg/mL
- Buffer
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-80 °C
- Stockage commentaire
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Date de péremption
- 24 months
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- Antigène
- BRCA1 (Breast Cancer 1 (BRCA1))
- Autre désignation
- BRCA1 (BRCA1 Produits)
- Sujet
- This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40 % of inherited breast cancers and more than 80 % of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
- Poids moléculaire
- 220kDa
- ID gène
- 672
- UniProt
- P38398
- Pathways
- Cycle Cellulaire, Réparation de l'ADN, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus
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