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Thyroglobulin anticorps

TG Reactivité: Humain, Souris, Rat IHC, FACS, StM Hôte: Souris Monoclonal 2H11 unconjugated
N° du produit ABIN6940704
  • Antigène Voir toutes Thyroglobulin (TG) Anticorps
    Thyroglobulin (TG)
    Reactivité
    • 102
    • 35
    • 35
    • 2
    • 1
    Humain, Souris, Rat
    Hôte
    • 62
    • 39
    • 4
    • 3
    • 1
    • 1
    Souris
    Clonalité
    • 66
    • 41
    Monoclonal
    Conjugué
    • 67
    • 11
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Thyroglobulin est non-conjugé
    Application
    • 42
    • 39
    • 26
    • 25
    • 16
    • 16
    • 11
    • 10
    • 8
    • 7
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Flow Cytometry (FACS), Staining Methods (StM)
    Specificité
    MAb 2H11 reacts with a partially defined epitope of human thyroglobulin. This epitope is different form the epitope recognized by MAb 6E1. Thyroglobulin is a 660 kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
    Purification
    Purified by Protein A/G
    Immunogène
    Human thyroid follicular cells
    Clone
    2H11
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product TG Anticorps primaire
  • Indications d'application

    Positive Control: Thyroid.

    Known Application: Flow Cytometry (0.5-1 μg/million cells), Immunohistochemistry (Formalin-fixed) (0.1-0.2 μg/mL, 30 min at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Date de péremption
    24 months
  • Antigène
    Thyroglobulin (TG)
    Autre désignation
    Thyroglobulin (Thyroidal Cell Marker) (TG Produits)
    Synonymes
    anticorps TG, anticorps cb717, anticorps AITD3, anticorps TGN, anticorps Tgn, anticorps cog, anticorps thyroglobulin, anticorps TG, anticorps tg, anticorps LOC701526, anticorps LOC701756, anticorps LOC100434297, anticorps Tg
    Poids moléculaire
    660kDa (Dimeric Form)
    ID gène
    7038
    UniProt
    P01266
    Pathways
    Thyroid Hormone Synthesis
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