TIMP2 anticorps (N-Term)

N° du produit ABIN6940735

Détail du produit anti-TIMP2 anticorps

Antigène: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Épitope: AA 56-66, N-Term

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Poisson zèbre (Danio rerio), Lapin, Cobaye

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TIMP2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Staining Methods (StM)

Specificité: It recognizes a protein of 21 kDa, identified as tissue inhibitor of metalloproteinases-2 (TIMP-2). It is closely related to TIMP-1 and shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92 kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.

Purification: Purified by Protein A/G

Immunogène: A synthetic peptide from the N-terminus of human TIMP2 protein (aa56-66) (DSGNDIYGNPI)

Clone: 3A4

Isotype: IgG2a kappa

Information d'application

Indications d'application:

Positive Control: HeLa cells. Normal Placenta. Breast, Colon, Endometrial, Prostate or Ovarian Carcinoma.

Known Application: Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (0.5-1 μg/mL), Western Blot (0.5-1 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur TIMP2

Antigène: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Autre désignation: TIMP2 (TIMP2 Produits)

Synonymes: anticorps CSC-21K, anticorps DDC8, anticorps timp2l, anticorps zgc:65967, anticorps zgc:85799, anticorps D11Bwg1104e, anticorps Timp-2, anticorps TIMP-2, anticorps etID32613.12, anticorps fa96h09, anticorps timp2, anticorps wu:fa96h09, anticorps zgc:136726, anticorps TIMP metallopeptidase inhibitor 2, anticorps TIMP metallopeptidase inhibitor 2b, anticorps tissue inhibitor of metalloproteinase 2, anticorps TIMP metallopeptidase inhibitor 2a, anticorps TIMP metallopeptidase inhibitor 2 L homeolog, anticorps TIMP2, anticorps timp2b, anticorps Timp2, anticorps timp2a, anticorps timp2.L

Poids moléculaire: 21kDa

ID gène: 7077

UniProt: P16035

Pathways: cAMP Metabolic Process