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XRCC3 anticorps

XRCC3 Reactivité: Humain WB, IHC, StM Hôte: Souris Monoclonal 10F1-6 unconjugated
N° du produit ABIN6940907
  • Antigène Voir toutes XRCC3 Anticorps
    XRCC3 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3))
    Reactivité
    • 41
    • 13
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 39
    • 5
    Souris
    Clonalité
    • 40
    • 4
    Monoclonal
    Conjugué
    • 33
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp XRCC3 est non-conjugé
    Application
    • 27
    • 15
    • 9
    • 7
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Staining Methods (StM)
    Purification
    Purified by Protein A/G
    Immunogène
    Recombinant full-length human XRCC3 protein
    Clone
    10F1-6
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product XRCC3 Anticorps primaire
  • Indications d'application

    Positive Control: Human placenta. HeLa nuclear extract.

    Known Application: Western Blot (0.5-1 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Date de péremption
    24 months
  • Antigène
    XRCC3 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3))
    Autre désignation
    XRCC3 (XRCC3 Produits)
    Synonymes
    anticorps CMM6, anticorps 4432412E01Rik, anticorps AI182522, anticorps AW537713, anticorps MGC69118, anticorps im:7142103, anticorps zgc:101608, anticorps si:dkey-11b8.1, anticorps xrcc3, anticorps XRCC3, anticorps X-ray repair cross complementing 3, anticorps X-ray repair complementing defective repair in Chinese hamster cells 3, anticorps X-ray repair complementing defective repair in Chinese hamster cells 3 L homeolog, anticorps XRCC3, anticorps Xrcc3, anticorps xrcc3.L, anticorps xrcc3
    Sujet
    The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC1 is a protein that facilitates the DNA base excision repair pathway by interacting with DNA ligase III and DNA polymerase to repair DNA single-strand breaks. XRCC2 and XRCC3 are both involved in maintaining chromosome stability during cell division. XRCC2 is required for efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids, and XRCC3 interacts directly with Rad51 to cooperate with Rad51 during recombinational repair. XRCC4 is an accessory factor of DNA Ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA Ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA Ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation.
    Poids moléculaire
    40kDa
    ID gène
    7517
    UniProt
    O43542
    Pathways
    Réparation de l'ADN
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