CA8 anticorps
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- Antigène Voir toutes CA8 Anticorps
- CA8 (Carbonic Anhydrase VIII (CA8))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CA8 est non-conjugé
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Application
- Immunohistochemistry (IHC), Staining Methods (StM)
- Purification
- Purified by Protein A/G
- Immunogène
- Recombinant full-length human CA8 protein
- Clone
- CPTC-CA8-2
- Isotype
- IgG2a kappa
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- Indications d'application
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Positive Control: Human cerebellum. Selective expression in purkinje cells. HEK-293 and K-562 cell lines.
Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
- Restrictions
- For Research Use only
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- Concentration
- 200 μg/mL
- Buffer
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-80 °C
- Stockage commentaire
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Date de péremption
- 24 months
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- Antigène
- CA8 (Carbonic Anhydrase VIII (CA8))
- Autre désignation
- CA8 (CA8 Produits)
- Synonymes
- anticorps AW546993, anticorps Ca8, anticorps Cals, anticorps Cals1, anticorps Carp, anticorps wdl, anticorps zgc:110118, anticorps CA-VIII, anticorps CALS, anticorps CAMRQ3, anticorps CARP, anticorps carbonic anhydrase 8, anticorps carbonic anhydrase VIII, anticorps CAH8, anticorps Car8, anticorps ca8, anticorps CA8
- Sujet
- The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in CA8 gene causes neuropathology, such as ataxia, mild mental retardation and the predisposition to quadrupedal gait. It is also associated with the development of colorectal and lung cancers. Additionally, it is upregulated in various cancers.
- Poids moléculaire
- 32.97kDa
- ID gène
- 767
- UniProt
- P35219
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