CAPNL1 anticorps

N° du produit ABIN6940954

Détail du produit anti-CAPNL1 anticorps

Antigène: CAPNL1 (Calpain 1, Large Subunit (CAPNL1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CAPNL1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Coating (Coat), Staining Methods (StM)

Purification: Purified by Protein A/G

Immunogène: Recombinant full-length human CAPN1 protein

Clone: CAPN1-1530

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Positive Control: HeLa cells. Skin or Tonsil.

Known Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur CAPNL1

Antigène: CAPNL1 (Calpain 1, Large Subunit (CAPNL1))

Autre désignation: CAPN1 (CAPNL1 Produits)

Synonymes: anticorps CANP, anticorps CANP1, anticorps CANPL1, anticorps muCANP, anticorps muCL, anticorps Capa-1, anticorps Capa1, anticorps mu-calpin, anticorps si:ch211-203k12.4, anticorps si:dkeyp-101g1.3, anticorps calpain, anticorps calpain 1, anticorps calpain 1, (mu/I) large subunit, anticorps calpain 1, (mu/I) large subunit b, anticorps calpain 11, anticorps CAPN1, anticorps Capn1, anticorps capn1, anticorps capn1b, anticorps CAPN11

Sujet: Calpain 1 is an intracellular calcium-dependent protease that cleaves cytoskeletal and sub-membranous proteins. Calpains are non-lysosomal, calcium-activated intracellular cysteine proteases. Calpains mediate specific Ca2+- dependent processes including cell fusion, mitosis and meiosis. Calpains are heterodimers of a small regulatory subunit and one of three large catalytic subunits, designated Calpain 1, Calpain 2 and Calpain p94. Calpastatin regulates Calpain by inhibiting both the proteolytic activity of Calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing. Calpain 1 co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Calpain influences the process of spermatogenesis and the events preceding fertilization, such as the acrosome reaction.

Poids moléculaire: 80kDa

ID gène: 823

UniProt: P07384

Pathways: Apoptose