Cyclin B2 anticorps
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- Antigène Voir toutes Cyclin B2 (CCNB2) Anticorps
- Cyclin B2 (CCNB2)
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Reactivité
- Humain, Souris, Rat, Xenopus laevis
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp Cyclin B2 est non-conjugé
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Application
- ELISA, Immunohistochemistry (IHC), Coating (Coat)
- Purification
- Purified by Protein A/G
- Immunogène
- Recombinant full-length Xenopus laevis Cyclin B2 protein
- Clone
- X29-2
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product CCNB2 Anticorps primaire
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- Indications d'application
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Positive Control: HeLa cells. Human cervical tissue (IHC).
Known Application: ELISA (For coating, order antibody without BSA), Optimal dilution for a specific application should be determined.
- Restrictions
- For Research Use only
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- Concentration
- 200 μg/mL
- Buffer
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-80 °C
- Stockage commentaire
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Date de péremption
- 24 months
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- Antigène
- Cyclin B2 (CCNB2)
- Autre désignation
- CCNB2 (CCNB2 Produits)
- Synonymes
- anticorps HsT17299, anticorps CycB2, anticorps sb:cb303, anticorps cycB2, anticorps LOC100136691, anticorps C-B2, anticorps cyclinb2, anticorps hst17299, anticorps LOC100282653, anticorps cyclin B2, anticorps cyclin B2 S homeolog, anticorps CCNB2, anticorps Ccnb2, anticorps ccnb2, anticorps LOC100136691, anticorps LOC100282653, anticorps ccnb2.S
- Sujet
- In eukaryotic cells, mitosis is initiated following the activation of a protein kinase known variously as maturation-promoting factor, M phase specific histone kinase or M-phase kinase. This protein kinase is composed of a catalytic subunit (Cdc2), a regulatory subunit (cyclin B) and a low molecular weight subunit (p13-Suc1). The Cdc/cyclin enzyme is subject to multiple levels of control, of which the regulation of the catalytic subunit by tyrosine phosphorylation is the best understood. Tyrosine phosphorylation inhibits the Cdc2/ cyclin B enzyme, and tyrosine dephosphorylation, occurring at the onset of mitosis, directly activates the pre-MPF complex. Evidence has established that B type cyclins not only act on M phase regulatory subunits of the Cdc2 protein kinase, but also activate the Cdc25A and Cdc25B endogenous tyrosine phosphatase, of which Cdc2 is the physiological substrate. The two B type cyclins, cyclin B1 and cyclin B2, have been shown to have distinct tissue distributions.
- Poids moléculaire
- 51kDa
- ID gène
- 9133
- UniProt
- O95067
- Pathways
- Cycle Cellulaire, M Phase
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