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Complement Factor H anticorps

CFH Reactivité: Humain WB, FACS, IF (cc) Hôte: Lapin Monoclonal 6F11 unconjugated
N° du produit ABIN6943395
  • Antigène Voir toutes Complement Factor H (CFH) Anticorps
    Complement Factor H (CFH)
    Reactivité
    • 63
    • 9
    • 7
    • 2
    • 1
    Humain
    Hôte
    • 48
    • 21
    • 3
    • 2
    Lapin
    Clonalité
    • 46
    • 27
    • 1
    Monoclonal
    Conjugué
    • 41
    • 9
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Cet anticorp Complement Factor H est non-conjugé
    Application
    • 51
    • 25
    • 23
    • 15
    • 15
    • 12
    • 11
    • 6
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc))
     Réactivité croisée
    Humain
    Purification
    Purified by Protein A.
    Immunogène
    Full length protein
    Clone
    6F11
    Isotype
    IgG
    Top Product
    Discover our top product CFH Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    FCM 1:20-100
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    Complement Factor H (CFH)
    Autre désignation
    Factor H (CFH Produits)
    Sujet

    Synonyms: Complement factor H, H factor 1, CFH, HF, HF1, HF2

    Background: A glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self-markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed.

    ID gène
    3075
    UniProt
    P08603
    Pathways
    Système du Complément, Cellular Response to Molecule of Bacterial Origin
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