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GLI3 anticorps

GLI3 Reactivité: Humain WB, IF (cc) Hôte: Lapin Monoclonal 45G1 unconjugated
N° du produit ABIN6943536
  • Antigène Voir toutes GLI3 Anticorps
    GLI3 (GLI Family Zinc Finger 3 (GLI3))
    Reactivité
    • 44
    • 24
    • 17
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 37
    • 5
    • 3
    Lapin
    Clonalité
    • 34
    • 11
    Monoclonal
    Conjugué
    • 24
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    Cet anticorp GLI3 est non-conjugé
    Application
    • 17
    • 13
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc))
     Réactivité croisée
    Humain
    Purification
    Purified by Protein A.
    Immunogène
    Recombinant protein within human Gli3 aa 1300-1600.
    Clone
    45G1
    Isotype
    IgG
    Top Product
    Discover our top product GLI3 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    GLI3 (GLI Family Zinc Finger 3 (GLI3))
    Autre désignation
    GLI3 (GLI3 Produits)
    Synonymes
    anticorps ACLS, anticorps GCPS, anticorps GLI3-190, anticorps GLI3FL, anticorps PAP-A, anticorps PAPA, anticorps PAPA1, anticorps PAPB, anticorps PHS, anticorps PPDIV, anticorps xgli3, anticorps AI854843, anticorps AU023367, anticorps Bph, anticorps Pdn, anticorps Xt, anticorps add, anticorps im:7142603, anticorps GLI3, anticorps GLI family zinc finger 3, anticorps GLI family zinc finger 3 L homeolog, anticorps GLI-Kruppel family member GLI3, anticorps GLI3, anticorps Gli3, anticorps gli3.L, anticorps gli3
    Sujet

    Synonyms: Transcriptional activator GLI3, GLI3 form of 190 kDa, GLI3 full-length protein, Transcriptional repressor GLI3R, GLI3 C-terminally truncated form, GLI3 form of 83 kDa, GLI3-190, GLI3FL, GLI3-83,

    Background: Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.

    ID gène
    2737
    UniProt
    P10071
    Pathways
    Signalisation Hedgehog
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