KDM4A anticorps
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- Antigène Voir toutes KDM4A Anticorps
- KDM4A (Lysine (K)-Specific Demethylase 4A (KDM4A))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp KDM4A est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF)
- Réactivité croisée
- Humain
- Purification
- Affinity purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.
- Immunogène
- Polyclonal antibody raised in rabbit against human JMJD2a (Jumonji domain containing 2a), using a KLH-conjugated synthetic peptide containing a sequence from the central part of the protein
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- Discover our top product KDM4A Anticorps primaire
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- Indications d'application
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WB 1:300-5000
ELISA 1:500-1000
IF() - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.6 μg/μL
- Buffer
- PBS with 0.05 % sodium azide and 0.05 % Proclin300.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C for 12 months.
- Date de péremption
- 12 months
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- Antigène
- KDM4A (Lysine (K)-Specific Demethylase 4A (KDM4A))
- Autre désignation
- JMJD2a (KDM4A Produits)
- Sujet
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Synonyms: JHDM3A, KDM4A, JMJD2, Lysine-specific demethylase 4A
Background: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.
- ID gène
- 9682
- UniProt
- O75164
- Pathways
- L'effet Warburg
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