SETD8 anticorps
-
- Antigène Voir toutes SETD8 Anticorps
- SETD8 (SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))
-
Reactivité
- Humain, Souris
-
Hôte
- Lapin
-
Clonalité
- Monoclonal
-
Conjugué
- Cet anticorp SETD8 est non-conjugé
-
Application
- Western Blotting (WB), Flow Cytometry (FACS)
- Réactivité croisée
- Humain, Souris
- Purification
- Purified by Protein A.
- Immunogène
- Synthetic peptide within human KMT5A 50-100
- Clone
- 2A1
- Isotype
- IgG
- Top Product
- Discover our top product SETD8 Anticorps primaire
-
-
- Indications d'application
-
WB 1:300-5000
FCM 1:20-100 - Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
- Date de péremption
- 12 months
-
- Antigène
- SETD8 (SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))
- Autre désignation
- KMT5A (SETD8 Produits)
- Synonymes
- anticorps KMT5A, anticorps PR-Set7, anticorps SET07, anticorps SET8, anticorps 2410195B05Rik, anticorps AA617402, anticorps AW536475, anticorps PR-SET7, anticorps setd8b, anticorps wu:fc23f12, anticorps zgc:171649, anticorps Pr-set7, anticorps RGD1305893, anticorps Setd8, anticorps kmt5a, anticorps kmt5a-a, anticorps setd8, anticorps setd8-a, anticorps set8a, anticorps setd8a, anticorps wu:fj33f02, anticorps zgc:153719, anticorps lysine methyltransferase 5A, anticorps lysine methyltransferase 5Ab, anticorps lysine methyltransferase 5A S homeolog, anticorps lysine methyltransferase 5Aa, anticorps KMT5A, anticorps Kmt5a, anticorps kmt5ab, anticorps kmt5a.S, anticorps kmt5aa
- Sujet
-
Synonyms: N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, Histone-lysine N-methyltransferase KMT5A, Lysine N-methyltransferase 5A, Lysine-specific methylase 5A, PR/SET domain-containing protein 07, SET domain-containing protein 8, PR-Set7, PR/SET07, KMT5A, PRSET7, SET07, SET8, SETD8
Background: Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.
- ID gène
- 387893
- UniProt
- Q9NQR1
-