Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

MUC4 anticorps

MUC4 Reactivité: Humain, Rat WB, IHC (p), FACS Hôte: Lapin Monoclonal 3A1 unconjugated
N° du produit ABIN6944168
  • Antigène Voir toutes MUC4 Anticorps
    MUC4 (Mucin 4, Cell Surface Associated (MUC4))
    Reactivité
    • 37
    • 12
    • 3
    Humain, Rat
    Hôte
    • 29
    • 9
    Lapin
    Clonalité
    • 22
    • 16
    Monoclonal
    Conjugué
    • 22
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp MUC4 est non-conjugé
    Application
    • 20
    • 8
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
     Réactivité croisée
    Humain, Rat
    Purification
    Purified by Protein A.
    Immunogène
    C terminal Human MUC4
    Clone
    3A1
    Isotype
    IgG
    Top Product
    Discover our top product MUC4 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    FCM 1:20-100
    IHC-P 1:200-400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    MUC4 (Mucin 4, Cell Surface Associated (MUC4))
    Autre désignation
    MUC4 (MUC4 Produits)
    Synonymes
    anticorps 4933405I11Rik, anticorps Asgp, anticorps ASGP, anticorps HSA276359, anticorps MUC-4, anticorps ASGP-1, anticorps Psmc, anticorps mucin 4, anticorps mucin 4, cell surface associated, anticorps Muc4, anticorps MUC4
    Sujet

    Synonyms: Mucin-4, Ascites sialoglycoprotein, Pancreatic adenocarcinoma mucin, Testis mucin, Tracheobronchial mucin, Mucin-4 alpha chain, Ascites sialoglycoprotein 1, Mucin-4 beta chain, Ascites sialoglycoprotein 2, MUC-4, ASGP, ASGP-1, ASGP-2, MUC4

    Background: May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.

    ID gène
    4585
    UniProt
    Q99102
    Pathways
    Regulation of Leukocyte Mediated Immunity
Vous êtes ici:
Support technique