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PABPN1 anticorps

PABPN1 Reactivité: Humain, Souris WB, IHC (p), FACS, IF (cc), IF (p) Hôte: Lapin Monoclonal 1C1 unconjugated
N° du produit ABIN6944405
  • Antigène Voir toutes PABPN1 Anticorps
    PABPN1 (Poly A Binding Protein Nuclear 1 (PABPN1))
    Reactivité
    • 39
    • 19
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    Humain, Souris
    Hôte
    • 39
    Lapin
    Clonalité
    • 31
    • 8
    Monoclonal
    Conjugué
    • 15
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp PABPN1 est non-conjugé
    Application
    • 24
    • 13
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Humain, Souris
    Purification
    Purified by Protein A.
    Immunogène
    N terminus human PABPN1
    Clone
    1C1
    Isotype
    IgG
    Top Product
    Discover our top product PABPN1 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    FCM 1:20-100
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C for 12 months.
    Date de péremption
    12 months
  • Antigène
    PABPN1 (Poly A Binding Protein Nuclear 1 (PABPN1))
    Autre désignation
    PABPN1 (PABPN1 Produits)
    Synonymes
    anticorps OPMD, anticorps PAB2, anticorps PABII, anticorps PABP-2, anticorps PABP2, anticorps Pabp3, anticorps mPABII, anticorps ARABIDOPSIS POLY(A) BINDING 2, anticorps ATPAB2, anticorps F28A23.130, anticorps F28A23_130, anticorps POLY(A) BINDING PROTEIN 2, anticorps POLY(A)-BINDING PROTEIN 2, anticorps poly(A) binding protein 2, anticorps opmd, anticorps pab2, anticorps pabp2, anticorps pabpii, anticorps pabpn1, anticorps Pabpn1, anticorps Poly(A)-binding protein 2, anticorps fb19c03, anticorps wu:fb17e03, anticorps wu:fb18c06, anticorps wu:fb19c03, anticorps zgc:85979, anticorps zgc:92452, anticorps poly(A) binding protein nuclear 1, anticorps poly(A) binding protein, nuclear 1, anticorps poly(A) binding protein 2, anticorps poly(A) binding protein, nuclear 1 S homeolog, anticorps poly(A) binding protein, nuclear 1 L homeolog, anticorps polyadenylate-binding protein 2, anticorps poly(A) binding protein Pab2, anticorps PABPN1, anticorps Pabpn1, anticorps PAB2, anticorps pabpn1.S, anticorps pabpn1.L, anticorps LOC100728725, anticorps pab2, anticorps pabpn1
    Sujet

    Synonyms: Polyadenylate-binding protein 2, Nuclear poly(A)-binding protein 1, Poly(A)-binding protein II, Polyadenylate-binding nuclear protein 1, PABP-2, Poly(A)-binding protein 2, PABII, PABPN1

    Background: Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484).

    ID gène
    8106
    UniProt
    Q86U42
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