PARP2 anticorps

N° du produit ABIN6944437

Détail du produit anti-PARP2 anticorps

Antigène: PARP2 (Poly (ADP-Ribose) Polymerase 2 (PARP2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp PARP2 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: Recombinant protein within the C-terminus of human PARP2.

Clone: 19A1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
FCM 1:20-100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 12 months

Détails sur PARP2

Antigène: PARP2 (Poly (ADP-Ribose) Polymerase 2 (PARP2))

Autre désignation: PARP2 (PARP2 Produits)

Synonymes: anticorps ADPRT2, anticorps ADPRTL2, anticorps ADPRTL3, anticorps ARTD2, anticorps PARP-2, anticorps pADPRT-2, anticorps Adprt2, anticorps Adprtl2, anticorps Aspartl2, anticorps C78626, anticorps cb996, anticorps adprtl2, anticorps ADPRT-2, anticorps APP, anticorps ATPARP1, anticorps PARP1, anticorps POLY(ADP-RIBOSE) POLYMERASE, anticorps POLY(ADP-RIBOSE) POLYMERASE 1, anticorps PP, anticorps T14P8.19, anticorps T14P8_19, anticorps poly(ADP-ribose) polymerase, anticorps poly(ADP-ribose) polymerase 2, anticorps poly(ADP-ribose) polymerase 2, anticorps poly (ADP-ribose) polymerase family, member 2, anticorps poly (ADP-ribose) polymerase 2, anticorps poly(ADP-ribose) polymerase 2 S homeolog, anticorps poly(ADP-ribose) polymerase, anticorps PARP2, anticorps Parp2, anticorps parp2, anticorps parp2.S

Sujet:

Synonyms: Poly [ADP-ribose] polymerase 2, ADP-ribosyltransferase diphtheria toxin-like 2, NAD(+) ADP-ribosyltransferase 2, Poly[ADP-ribose] synthase 2, PARP-2, hPARP-2, ARTD2, ADPRT-2, pADPRT-2, PARP2, ADPRT2, ADPRTL2

Background: Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD+ is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Also mediates serine ADP-ribosylation of target proteins following interaction with HPF1, HPF1 conferring serine specificity. In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex

ID gène: 10038

UniProt: Q9UGN5

Pathways: Réparation de l'ADN