PHD1 anticorps
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- Antigène Voir toutes PHD1 (EGLN2) Anticorps
- PHD1 (EGLN2) (Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp PHD1 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Réactivité croisée
- Humain, Souris, Rat
- Purification
- Purified by Protein A.
- Immunogène
- Recombinant human PHD1/prolyl hydroxylase between 1 to 100 amino acids.
- Clone
- 7G8
- Isotype
- IgG
- Top Product
- Discover our top product EGLN2 Anticorps primaire
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- Indications d'application
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WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(ICC) 1:50-200
IHC() - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C for 12 months.
- Date de péremption
- 12 months
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- Antigène
- PHD1 (EGLN2) (Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2))
- Autre désignation
- PHD1/prolyl hydroxylase (EGLN2 Produits)
- Synonymes
- anticorps egln2, anticorps phd2, anticorps PHD1, anticorps 0610011A13Rik, anticorps C85656, anticorps Hif-p4h-1, anticorps Ier4, anticorps Phd1, anticorps SM-20, anticorps HIF-PH1, anticorps HPH-1, anticorps HPH-3, anticorps PHD-1, anticorps EIT6, anticorps HIFPH1, anticorps egl-9 family hypoxia-inducible factor 1, anticorps egl-9 family hypoxia inducible factor 2, anticorps Egl nine homolog 2, anticorps egl-9 family hypoxia-inducible factor 2 L homeolog, anticorps egl-9 family hypoxia-inducible factor 2, anticorps egln1, anticorps EGLN2, anticorps egln2, anticorps egln2.L, anticorps Egln2
- Sujet
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Synonyms: Egl nine homolog 2, Estrogen-induced tag 6, HPH-3, Hypoxia-inducible factor prolyl hydroxylase 1, Prolyl hydroxylase domain-containing protein 1, HIF-PH1, HIF-prolyl hydroxylase 1, HPH-1, PHD1, EGLN2
Background: Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle. Also regulates susceptibility to normoxic oxidative neuronal death. Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation. Hydroxylates IKBKB, mediating NF-kappaB activation in hypoxic conditions. Target proteins are preferentially recognized via a LXXLAP motif.
- ID gène
- 112398
- UniProt
- Q96KS0
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway, Cell RedoxHomeostasis
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