PRPF8 anticorps

N° du produit ABIN6944681

Détail du produit anti-PRPF8 anticorps

Antigène: PRPF8 (PRP8 Pre-mRNA Processing Factor 8 (PRPF8))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp PRPF8 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: Recombinant protein within 1200 of human PRPF8.

Clone: 1A7

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 12 months

Détails sur PRPF8

Antigène: PRPF8 (PRP8 Pre-mRNA Processing Factor 8 (PRPF8))

Autre désignation: PRPF8 (PRPF8 Produits)

Synonymes: anticorps id:ibd1257, anticorps ik:tdsubc_2a9, anticorps im:7141966, anticorps tdsubc_2a9, anticorps wu:fb37c02, anticorps wu:fb73e06, anticorps xx:tdsubc_2a9, anticorps zgc:56504, anticorps hprp8, anticorps prp-8, anticorps prp8, anticorps prpc8, anticorps rp13, anticorps HPRP8, anticorps PRP8, anticorps PRPC8, anticorps RP13, anticorps SNRNP220, anticorps AU019467, anticorps D11Bwg0410e, anticorps DBF3/PRP8, anticorps Prp8, anticorps Sfprp8l, anticorps pre-mRNA processing factor 8, anticorps pre-mRNA processing factor 8 S homeolog, anticorps Prpf8, anticorps prpf8, anticorps prpf8.S, anticorps PRPF8

Sujet:

Synonyms: Pre-mRNA-processing-splicing factor 8, 220 kDa U5 snRNP-specific protein, PRP8 homolog, Splicing factor Prp8, p220, PRPF8, PRPC8

Background: PRP8, also designated pre-mRNA-processing-splicing factor 8, is a highly conserved nuclear protein and a central component of the catalytic core of the spliceosome, where it may be involved in various molecular rearrangements. PRP8, which is widely expressed, plays a role in transesterification reactions that regulate splicesome-induced pre-mRNA splicing. Specifically, PRP8 interacts with the GU dinucleotide at the 5' splice site (5'SS) and forms a specific UV-inducible cross-link. It also interacts functionally with the 3'SS, affecting the efficiency of the second catalytic step. PRP8 may play a role in the first transesterification step, as PRP8 mutations that prohibit negative regulation of PRP28 or PRP44/Brr2 subsequently block U4 activation. In addition, PRP8 interacts with a conserved region of U6 that is instrumental in the formation of the catalytic core of the spliceosome.

ID gène: 10594

UniProt: Q6P2Q9