Transferrin Receptor 2 anticorps
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- Antigène Voir toutes Transferrin Receptor 2 (TFR2) Anticorps
- Transferrin Receptor 2 (TFR2)
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp Transferrin Receptor 2 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Réactivité croisée
- Humain
- Purification
- Purified by Protein A.
- Immunogène
- Recombinant protein within human Transferrin Receptor 2 aa 100-300.
- Clone
- 1G4
- Isotype
- IgG
- Top Product
- Discover our top product TFR2 Anticorps primaire
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- Indications d'application
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WB 1:300-5000
IHC-P 1:200-400 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- Transferrin Receptor 2 (TFR2)
- Autre désignation
- TFR2 (TFR2 Produits)
- Sujet
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Synonyms: Transferrin receptor protein 2, TFR2, HFE3
Background: Iron is a vital molecule for living organisms because it is involved in a wide variety of metabolic processes, such as oxygen transport, DNA synthesis and electron transport. Excessive iron uptake leads to tissue damage as a result of formation of free radicals. Iron uptake and storage is tightly regulated by the feedback system of iron responsive element-containing gene products and iron regulatory proteins that modulate the expression levels of the genes involved in iron metabolism. The transferrin receptor 2 (TFR2) mediates the uptake of transferrin-bound iron. It is involved in iron metabolism, hepatocyte function and erythrocyte differentiation, and is highly expressed as a protein in liver as well as in hepatocytes and erythroid precursors. The gene encoding human TRF2 maps to chromosome 7q22 and is expressed as an a isoform, which encodes a transmembrane protein, and a b isoform, which encodes a shorter, intracellular protein. Mutations in the TFR2 gene result in hereditary hemochromatosis type III (HFE3), an iron overloading disorder that results in clinical complications, including cirrhosis, cardiopathy, diabetes, endocrine dysfunctions, arthropathy and susceptibility to liver cancer.
- ID gène
- 7036
- UniProt
- Q9UP52
- Pathways
- Transition Metal Ion Homeostasis
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