TREX1 anticorps
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- Antigène Voir toutes TREX1 Anticorps
- TREX1 (three Prime Repair Exonuclease 1 (TREX1))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp TREX1 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Humain
- Purification
- Purified by Protein A.
- Immunogène
- Recombinant protein within human TREX1 aa 100-300.
- Clone
- 6C2
- Isotype
- IgG
- Top Product
- Discover our top product TREX1 Anticorps primaire
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- Indications d'application
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WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- TREX1 (three Prime Repair Exonuclease 1 (TREX1))
- Autre désignation
- TREX1 (TREX1 Produits)
- Synonymes
- anticorps AGS1, anticorps CRV, anticorps DRN3, anticorps HERNS, anticorps 1661, anticorps AU041952, anticorps RGD1309596, anticorps three prime repair exonuclease 1, anticorps CpipJ_CPIJ012074, anticorps Tsp_03749, anticorps TREX1, anticorps Trex1
- Sujet
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Synonyms: Three-prime repair exonuclease 1, 3'-5' exonuclease TREX1, Deoxyribonuclease III, DNase III, TREX1
Background: Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
- ID gène
- 11277
- UniProt
- Q9NSU2
- Pathways
- Apoptose
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