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TREX1 anticorps

TREX1 Reactivité: Humain WB, IHC (p), IF (cc), IF (p) Hôte: Lapin Monoclonal 6C2 unconjugated
N° du produit ABIN6945219
  • Antigène Voir toutes TREX1 Anticorps
    TREX1 (three Prime Repair Exonuclease 1 (TREX1))
    Reactivité
    • 34
    • 6
    • 5
    Humain
    Hôte
    • 27
    • 8
    Lapin
    Clonalité
    • 24
    • 11
    Monoclonal
    Conjugué
    • 20
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp TREX1 est non-conjugé
    Application
    • 21
    • 9
    • 7
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Humain
    Purification
    Purified by Protein A.
    Immunogène
    Recombinant protein within human TREX1 aa 100-300.
    Clone
    6C2
    Isotype
    IgG
    Top Product
    Discover our top product TREX1 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    TREX1 (three Prime Repair Exonuclease 1 (TREX1))
    Autre désignation
    TREX1 (TREX1 Produits)
    Synonymes
    anticorps AGS1, anticorps CRV, anticorps DRN3, anticorps HERNS, anticorps 1661, anticorps AU041952, anticorps RGD1309596, anticorps three prime repair exonuclease 1, anticorps CpipJ_CPIJ012074, anticorps Tsp_03749, anticorps TREX1, anticorps Trex1
    Sujet

    Synonyms: Three-prime repair exonuclease 1, 3'-5' exonuclease TREX1, Deoxyribonuclease III, DNase III, TREX1

    Background: Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.

    ID gène
    11277
    UniProt
    Q9NSU2
    Pathways
    Apoptose
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