NK-1.1/CD161c anticorps (PerCP-Cy5.5)

N° du produit ABIN7278489

Détail du produit anti-NK-1.1/CD161c anticorps (PerCP-Cy5.5)

Antigène: NK-1.1/CD161c (NK-1.1)

Reactivité: Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NK-1.1/CD161c est conjugé à/à la PerCP-Cy5.5

Application: Flow Cytometry (FACS)

Purification: This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation. It is recommended to store the product undiluted at 4°C, and protected from prolonged exposure to light. Do not freeze.

Clone: PK136

Isotype: IgG2a kappa

Information d'application

Indications d'application: This antibody preparation has been quality-tested for flow cytometry using mouse spleen cells, or an appropriate cell type (where indi- cated). The amount of antibody required for optimal staining of a cell sample should be determined empirically in your system.

Commentaires:

0.2 mg/mL

Restrictions: For Research Use only

Stockage

Buffer: 10 mM NaH2PO4, 150 mM NaCl, 0.09 % Sodium azide, 0.1 % gelatin, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: 2-8°C protected from light

Date de péremption: 12 months

Détails sur NK-1.1/CD161c

Antigène: NK-1.1/CD161c (NK-1.1)

Autre désignation: NK1.1 (CD161) (NK-1.1/CD161c Produits)

Synonymes: anticorps AI462337, anticorps CD161, anticorps Ly-59, anticorps Ly55c, anticorps Ly59, anticorps NK-RP1, anticorps NK1.1, anticorps NKR-P1.9, anticorps NKRP1, anticorps NKRP140, anticorps Nk-1, anticorps Nk-1.2, anticorps Nk1, anticorps Nk1.2, anticorps Nkrp1c, anticorps ly-55c, anticorps killer cell lectin-like receptor subfamily B member 1C, anticorps Klrb1c

Sujet: The PK136 antibody is specific for mouse NK1.1, a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. NK1.1 is prominently expressed on natural killer (NK) cells, and is correlated with NK cytotoxic effects toward virus-infected cells and tumor cells. NK1.1 is expressed on subsets of NKT cells in certain mouse strains (C57BL/6, FVB/N, and NZB), yet absent from others (AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129). Putative subsets of NK cells and their expression of NK1.1 antigen are of continuing interest, including NK1.1+/CD117+ (c-Kit) cells reported to be immunosuppressive for CD8+ T cells in a mechanism involving PD-1 and PD-L1 (Ehlers et al. 2012. Endocrinology. 10: 1247).. The PK136 antibody may be used for detection of NK1.1 expression on mouse strains including CE, B6, NZB, C58, Ma/My, ST, SJL, and FVB. The antibody is reported to react with an epitope common to NKR-P1B and NKR-P1C alloantigenic forms of NK1.1 (Carlyle et al. 2006. J. Immunol. 176: 7511-7524).

ID gène: 17059

UniProt: P27814