DDB1 anticorps (C-Term)

N° du produit ABIN6971574

Détail du produit anti-DDB1 anticorps

Antigène: DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDB1 est non-conjugé

Application: Western Blotting (WB)

Attributs du produit: DDB1 (DNA damage-binding protein 1, HBV X-associated protein 1, XAP-1, Xeroderma pigmentosum group E-complementing protein) is a DNA binding protein that associates with DNA following UV damage and functions in excision repair. In addition to its function in DNA repair, DDB1 plays a role in normal mitotic exit by regulating Anaphase Promoting Complex (APC) activity. Depletion of DDB1 in mitotic cells significantly delays mitotic exit. DDB1 facilitates the binding of substrates to the Cul4-Roc1 complex and the ubiquitination of selected proteins, including histones H2A, H3 and H4 localized to the sites of DNA damage. It is also involved in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of P53 in response to radiation-induced DNA damage and during DNA replication. In mouse studies, it was identified that loss of DDB1 function prevents hepatocytes from replicating DNA, inducing compensatory proliferation of normal hepatocytes that leads to development of hepatocellular carcinoma. DDB1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.

Purification: Affinity Purified

Immunogène: This DDB1 antibody was raised against a peptide from the C-terminus of human DDB1.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Détails sur DDB1

Antigène: DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))

Autre désignation: DDB1 (DDB1 Produits)

Synonymes: anticorps DDBA, anticorps UV-DDB1, anticorps XAP1, anticorps XPCE, anticorps XPE, anticorps XPE-BF, anticorps DDB1, anticorps xpe, anticorps ddba, anticorps xap1, anticorps xpce, anticorps xpe-bf, anticorps uv-ddb1, anticorps ddb1, anticorps 127kDa, anticorps AA408517, anticorps p127-Ddb1, anticorps damage specific DNA binding protein 1, anticorps damage-specific DNA binding protein 1, 127kDa, anticorps DNA damage-binding protein 1, anticorps damage-specific DNA binding protein 1, anticorps DDB1, anticorps ddb1, anticorps LOC100187356, anticorps Ddb1, anticorps ddb-1

Poids moléculaire: 140 kDa

NCBI Accession: NP_001914

Pathways: Réparation de l'ADN