DOT1L anticorps (C-Term)

N° du produit ABIN6971602

Détail du produit anti-DOT1L anticorps

Antigène: DOT1L (DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DOT1L est non-conjugé

Application: Western Blotting (WB)

Attributs du produit: DOT1L (Disruptor of Telomeric silencing 1-like, also known as KMT4) is the mammalian homologue of the yeast Dot1 protein and the Drosophila Grappa protein. DOTL1 is the enzyme responsible for lysine 79 methylation of histone H3. DOT1L can promote an oncogenic pattern of gene expression through binding with several MLL fusion partners found in acute leukemia, thus leading to aberrant methylation of lysine 79 at MLL target genes. In contrast to most other histone lysine methyltransferases, DOT1L does not contain a SET domain. Biochemical studies suggest that recombinant DOT1L is active on recombinant nucleosomes. DOT1L antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.

Purification: Affinity Purified

Immunogène: This DOT1L antibody was raised against a peptide derived from the C-terminal region of human DOT1L.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Détails sur DOT1L

Antigène: DOT1L (DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L))

Autre désignation: DOT1L (DOT1L Produits)

Synonymes: anticorps NV11307, anticorps DOT1L, anticorps DOT1, anticorps KMT4, anticorps A630076O07, anticorps AW907654, anticorps Dot1, anticorps mDot1, anticorps histone-lysine N-methyltransferase, H3 lysine-79 specific, anticorps DOT1 like histone lysine methyltransferase, anticorps histone methyltransferase, anticorps DOT1-like, histone H3 methyltransferase (S. cerevisiae), anticorps LOC100116648, anticorps DOT1L, anticorps DOT1, anticorps Dot1l

Poids moléculaire: 200 kDa

NCBI Accession: NP_115871