GFI1 anticorps (N-Term)

N° du produit ABIN6971682

Détail du produit anti-GFI1 anticorps

Antigène: GFI1 (Growth Factor Independent 1 (GFI1))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GFI1 est non-conjugé

Application: Western Blotting (WB)

Attributs du produit: GFI1 (growth factor independent 1 transcription repressor) is a transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters. Required for the maintenance of inner ear hair cells. GFI1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.

Purification: Affinity Purified

Immunogène: This antibody was raised against a peptide within the N-terminal region of human GFI1.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Détails sur GFI1

Antigène: GFI1 (Growth Factor Independent 1 (GFI1))

Autre désignation: GFI1 (GFI1 Produits)

Synonymes: anticorps AW495828, anticorps Gfi-1, anticorps Pal-1, anticorps Pal1, anticorps GFI1, anticorps GFI-1, anticorps GFI1A, anticorps SCN2, anticorps ZNF163, anticorps growth factor independent 1, anticorps growth factor independent 1 transcriptional repressor, anticorps Gfi1, anticorps GFI1

Poids moléculaire: 55 kDa

NCBI Accession: NP_005254