H2AFZ anticorps (C-Term)

N° du produit ABIN6971773

Détail du produit anti-H2AFZ anticorps

Antigène: H2AFZ (H2A Histone Family, Member Z (H2AFZ))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp H2AFZ est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Chromatin Immunoprecipitation (ChIP), ChIP DNA-Sequencing (ChIP-seq), Dot Blot (DB)

Attributs du produit: The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Histone H1 is a linker histone, present at the interface between the nucleosome core and DNA entry/exit points, it is responsible for establishing higher-order chromatin structure. Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins and the methylation of cytosine residues in the DNA. Reported histone modifications include acetylation, methylation, phosphorylation, ubiquitylation, glycosylation, ADP-ribosylation, carbonylation and SUMOylation, they play a major role in regulating gene expression. Histone H2A.Z (H2AZ, H2AFZ) is a histone H2A variant, a protein similar to canonical H2A but with different molecular identity and unique functions. H2A.Z is highly conserved during evolution. It plays an important role in basic cellular mechanisms such as gene activation, chromosome segregation, heterochromatic silencing and progression through the cell cycle. H2A.Z is acetylated at multiple lysine residues in its amino terminus, which may enable H2A.Z to function as an insulator of chromatin domains. Histone H2A.Z antibody (pAb) (H2AZ) was raised in a Rabbit host. It has been validated for use in Chromatin Immunoprecipitation, ChIP-Seq, Dot blot, Immunocytochemistry, Immunofluorescence and Western blot, it has been shown to react with Human samples, but it is predicted that it will react with a wide range of sample types.

Purification: Protein A Chromatography

Immunogène: This Histone H2A.Z antibody was raised against a peptide derived from the C-terminus of human histone H2A.Z.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Détails sur H2AFZ

Antigène: H2AFZ (H2A Histone Family, Member Z (H2AFZ))

Autre désignation: Histone H2A.Z (H2AFZ Produits)

Synonymes: anticorps H2A.Z-1, anticorps H2A.z, anticorps H2A/z, anticorps H2AZ, anticorps H2A.Z, anticorps H2a.z-1, anticorps H2AFV, anticorps H2Az, anticorps XH2AZ, anticorps h2a.zl1, anticorps h2a.zl2, anticorps H2A histone family member Z, anticorps H2A histone family, member Z, anticorps H2A histone family member Z L homeolog, anticorps histone H2A.Z, anticorps H2AFZ, anticorps H2afz, anticorps h2afz.L

Poids moléculaire: 14 kDa

NCBI Accession: NP_002097

Pathways: Telomere Maintenance