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Rpb1 CTD anticorps (pSer2)

Reactivité: Humain WB, IF, ICC Hôte: Rat Monoclonal 3E7C7 unconjugated
N° du produit ABIN6972624
  • Antigène Tous les produits Rpb1 CTD
    Rpb1 CTD (RNA Polymerase II CTD)
    Épitope
    • 16
    • 10
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    pSer2
    Reactivité
    • 38
    • 21
    • 16
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 23
    • 10
    • 5
    Rat
    Clonalité
    • 23
    • 15
    Monoclonal
    Conjugué
    • 24
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp Rpb1 CTD est non-conjugé
    Application
    • 24
    • 17
    • 14
    • 10
    • 7
    • 4
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Attributs du produit
    RNA pol II (RNA polymerase II) is responsible for synthesizing messenger RNA in eukaryotes. RNA pol II contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, RNA pol II, in combination with several other polymerase subunits, form the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. During the transcription cycle, the CTD of the large subunit of RNA pol II is reversibly phosphorylated. RNA pol II containing unphosphorylated CTD is recruited to the promoter, whereas the hyperphosphorylated CTD form is involved in active transcription. Phosphorylation occurs at two sites within the heptapeptide repeat, at serine 2, serine 5 and serine 7. RNA pol II phosphorylated at serine 2 is enriched over the gene body and is associated with transcriptional elongation. RNA pol II CTD phospho Ser2 antibody (mAb) (Clone 3E7C7) was raised in a Rat host. It has been validated for use in Immunocytochemistry, Immunofluorescence and Western blot, it has been shown to react with Human samples.
    Purification
    Protein G Chromatography
    Immunogène
    This antibody was raised against a peptide containing the RNA pol II CTD sequence phosphorylated at serine 2.
    Clone
    3E7C7
    Isotype
    IgG2a
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
  • Antigène
    Rpb1 CTD (RNA Polymerase II CTD)
    Autre désignation
    RNA pol II CTD (Rpb1 CTD Produits)
    Synonymes
    anticorps 5, anticorps 8WG16, anticorps CG1554, anticorps CTD, anticorps Dmel\\CG1554, anticorps H5, anticorps II, anticorps L5, anticorps POL, anticorps Pol II, anticorps Pol II CTD, anticorps Pol II Ser5P, anticorps Pol II0[ser2], anticorps Pol II0[ser5], anticorps Pol II[ser2], anticorps Pol IIa, anticorps Pol IIo, anticorps Pol IIo[Ser2], anticorps Pol IIo[ser2], anticorps Pol IIo[ser5], anticorps Pol-IIa, anticorps PolII, anticorps PolIIo, anticorps RNA Pol II, anticorps RNA Pol II CTD, anticorps RNA PolI 215, anticorps RNA PolII, anticorps RNA pol II, anticorps RNA pol IIo, anticorps RNA polII, anticorps RNAP, anticorps RNAP II, anticorps RNAP II LS, anticorps RNAPII, anticorps RNAPII0, anticorps RNApol2, anticorps RNApolII, anticorps RPB1, anticorps RPII215, anticorps RpII, anticorps Rpb1, anticorps Rpll215, anticorps Ubl, anticorps dRPB1, anticorps dRpb1, anticorps l(1)10Ca, anticorps l(1)DC912, anticorps l(1)DF912, anticorps l(1)G0040, anticorps l(1)L5, anticorps pol II, anticorps polII, anticorps RNA polymerase II 215kD subunit, anticorps RpII215
    Poids moléculaire
    240 kDa
    NCBI Accession
    NP_000928
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