SUPT16H anticorps

N° du produit ABIN6972824

Détail du produit anti-SUPT16H anticorps

Antigène: SUPT16H (FACT complex subunit SPT16 (SUPT16H))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SUPT16H est non-conjugé

Application: Western Blotting (WB)

Attributs du produit: Supt16H / Supt16 (suppressor of Ty 16 homolog (S. cerevisiae)) is a component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene (By similarity). Supt16H / Spt16 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.

Purification: Affinity Purified

Immunogène: This antibody was raised against a synthetic peptide containing human Supt16H / Spt16.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Détails sur SUPT16H

Antigène: SUPT16H (FACT complex subunit SPT16 (SUPT16H))

Autre désignation: Supt16H / Spt16 (SUPT16H Produits)

Synonymes: anticorps CDC68, anticorps FACTP140, anticorps SPT16/CDC68, anticorps CG1828, anticorps DRE4/dSPT16, anticorps Dmel\\CG1828, anticorps SPT16, anticorps Spt16, anticorps dSPT16, anticorps dSpt16, anticorps dspt16, anticorps l(3)62Bg, anticorps l(3)dre4, anticorps spt16, anticorps Cdc68, anticorps Fact140, anticorps Supt16h, anticorps T12H20.3, anticorps T12H20_3, anticorps global transcription factor C, anticorps SSF1, anticorps DDBDRAFT_0204912, anticorps DDBDRAFT_0231753, anticorps DDB_0204912, anticorps DDB_0231753, anticorps DUF140, anticorps SPT16 homolog, facilitates chromatin remodeling subunit, anticorps FACT complex subunit spt16, anticorps FACT complex subunit SPT16, anticorps CG1828 gene product from transcript CG1828-RB, anticorps suppressor of Ty 16, anticorps global transcription factor C, anticorps chromatin-remodeling protein SPT16, anticorps FACT complex component Spt16, anticorps chromatin-remodeling protein, anticorps global regulator of transcription, anticorps FACT (FAcilitates Chromatin Transcription) complex subunit, putative, anticorps SPT16 homolog, facilitates chromatin remodeling subunit S homeolog, anticorps SUPT16H, anticorps AOR_1_1808194, anticorps CC1G_05155, anticorps dre4, anticorps Supt16, anticorps SPT16, anticorps spt16, anticorps CDC68, anticorps Supt16h, anticorps supt16h, anticorps supt16h.S

Poids moléculaire: 140 kDa

NCBI Accession: NP_009123

Pathways: Chromatin Binding