TEAD1 anticorps

N° du produit ABIN6972853

Détail du produit anti-TEAD1 anticorps

Antigène: TEAD1 (TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TEAD1 est non-conjugé

Application: Western Blotting (WB)

Attributs du produit: TEAD1 (TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor)) is a transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. TEAD1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.

Purification: Affinity Purified

Immunogène: This antibody was raised against a recombinant protein fragment within human TEAD1.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Détails sur TEAD1

Antigène: TEAD1 (TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1))

Autre désignation: TEAD1 (TEAD1 Produits)

Synonymes: anticorps tead1, anticorps zgc:63696, anticorps TEAD1, anticorps xtead1, anticorps 2610024B07Rik, anticorps B230114H05Rik, anticorps Gtrgeo5, anticorps TEAD-1, anticorps TEF-1, anticorps Tcf13, anticorps mTEF-1, anticorps AA, anticorps NTEF-1, anticorps REF1, anticorps TCF-13, anticorps TCF13, anticorps XNTEF-1, anticorps xlNTEF-1, anticorps TEA domain family member 1a, anticorps TEA domain transcription factor 1, anticorps TEA domain family member 1 (SV40 transcriptional enhancer factor), anticorps TEA domain family member 1, anticorps TEA domain family member 1 (SV40 transcriptional enhancer factor) S homeolog, anticorps TEA domain family member 1b, anticorps tead1a, anticorps TEAD1, anticorps tead1, anticorps Tead1, anticorps tead1.S, anticorps tead1b

Poids moléculaire: 60 kDa

NCBI Accession: NP_068780

Pathways: Regulation of Lipid Metabolism by PPARalpha