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Ubinuclein 1 anticorps (AA 1-345)

UBN1 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6972900
  • Antigène Voir toutes Ubinuclein 1 (UBN1) Anticorps
    Ubinuclein 1 (UBN1)
    Épitope
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-345
    Reactivité
    • 30
    • 15
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 25
    • 4
    • 1
    Lapin
    Clonalité
    • 26
    • 4
    Polyclonal
    Conjugué
    • 16
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp Ubinuclein 1 est non-conjugé
    Application
    • 10
    • 8
    • 5
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Attributs du produit
    UBN1 (Ubinuclein 1, also known as HIRA binding protein) is a ubiquitously expressed nuclear protein that acts as a novel regulator of senescence. UBN1 is involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. It is expressed in a number of cancer cell lines and tumors and may be required for replication-independent chromatin assembly. UBN1 is part of a large multi-subunit protein complex that interacts with CEBPA and Epstein-Barr virus BLZF1. It co-localizes with HIRA, PML and SP100 in the PML bodies of senescent cells. When overexpressed, UBN1 accumulates in the nucleus of cells defective for cytokinesis. Ubn1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.
    Purification
    Affinity Purified
    Immunogène
    This Ubinuclein antibody was raised against a recombinant protein corresponding to amino acids 1-345 of human Ubn1.
    Isotype
    IgG
    Top Product
    Discover our top product UBN1 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
  • Antigène
    Ubinuclein 1 (UBN1)
    Autre désignation
    Ubn1 (UBN1 Produits)
    Synonymes
    anticorps ubinuclein-1, anticorps ubn1, anticorps VT, anticorps VT4, anticorps 1110029L11Rik, anticorps 2610108L02Rik, anticorps AA673476, anticorps AW124741, anticorps ubinuclein 1, anticorps UBN1, anticorps ubn1, anticorps Ubn1
    Poids moléculaire
    145 kDa
    NCBI Accession
    NP_001072982
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