KPNA6 anticorps (AA 101-200) (AbBy Fluor® 555)
-
- Antigène Voir toutes KPNA6 Anticorps
- KPNA6 (Karyopherin alpha 6 (Importin alpha 7) (KPNA6))
-
Épitope
- AA 101-200
-
Reactivité
- Humain, Souris
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp KPNA6 est conjugé à/à la AbBy Fluor® 555
-
Application
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Humain, Souris
- Homologie
- Rat,Cow,Sheep,Pig,Horse,Chicken
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human KPNA6
- Isotype
- IgG
- Top Product
- Discover our top product KPNA6 Anticorps primaire
-
-
- Indications d'application
-
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
-
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
-
- Antigène
- KPNA6 (Karyopherin alpha 6 (Importin alpha 7) (KPNA6))
- Autre désignation
- KPNA6 (KPNA6 Produits)
- Synonymes
- anticorps IPOA7, anticorps Kpna5, anticorps NPI-2, anticorps KPNA7, anticorps karyopherin subunit alpha 6, anticorps karyopherin (importin) alpha 6, anticorps karyopherin alpha 6 (importin alpha 7), anticorps karyopherin alpha 6 (importin alpha 7) S homeolog, anticorps KPNA6, anticorps Kpna6, anticorps kpna6.S
- Sujet
-
Synonyms: Importin subunit alpha-7, KPNA6, Karyopherin subunit alpha-6, KPNA6, IPOA7
Background: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
- ID gène
- 23633
- UniProt
- O60684
- Pathways
- Protein targeting to Nucleus
-