Importin 8 anticorps (AA 1-100) (Biotin)

N° du produit ABIN6982735

Détail du produit anti-Importin 8 anticorps (Biotin)

Antigène: Importin 8 (IPO8)

Épitope: AA 1-100

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Importin 8 est conjugé à/à la Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Rat

Homologie: Human,Mouse,Cow,Sheep,Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Importin 8

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur Importin 8

Antigène: Importin 8 (IPO8)

Autre désignation: Importin 8 (IPO8 Produits)

Synonymes: anticorps IPO8, anticorps si:ch211-116i17.1, anticorps RANBP8, anticorps 6230418K12Rik, anticorps Abcc10, anticorps C130009K11Rik, anticorps MRP7, anticorps OM-1, anticorps Om1, anticorps Ranbp8, anticorps importin 8, anticorps IPO8, anticorps ipo8, anticorps Ipo8

Sujet:

Synonyms: FLJ26580, Imp 8, Imp8, Importin-8, Importin8, IPO 8, IPO8, IPO8_HUMAN, Ran binding protein 8, RAN BP8, Ran-binding protein 8, RANBP 8, RANBP8.

Background: Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19.

ID gène: 10526

UniProt: O15397