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DTX3L anticorps (AA 651-740) (FITC)

DTX3L Reactivité: Humain, Souris, Rat FACS, IF (cc), IF (p) Hôte: Lapin Polyclonal FITC
N° du produit ABIN6986786
  • Antigène Voir toutes DTX3L Anticorps
    DTX3L (Deltex E3 ubiquitin ligase 3L (DTX3L))
    Épitope
    • 15
    • 8
    • 7
    • 7
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 651-740
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 42
    • 3
    Lapin
    Clonalité
    • 43
    • 2
    Polyclonal
    Conjugué
    • 15
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp DTX3L est conjugé à/à la FITC
    Application
    • 23
    • 18
    • 13
    • 12
    • 12
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Humain, Souris, Rat
    Homologie
    Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human DTX3L
    Isotype
    IgG
    Top Product
    Discover our top product DTX3L Anticorps primaire
  • Indications d'application
    FCM 1:20-100
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    DTX3L (Deltex E3 ubiquitin ligase 3L (DTX3L))
    Autre désignation
    DTX3L (DTX3L Produits)
    Synonymes
    anticorps BBAP, anticorps RGD1565144, anticorps AU042200, anticorps BC023741, anticorps DTX3L, anticorps deltex E3 ubiquitin ligase 3L, anticorps deltex 3-like, E3 ubiquitin ligase, anticorps probable E3 ubiquitin-protein ligase DTX3, anticorps DTX3L, anticorps Dtx3l, anticorps LOC100521724
    Sujet

    Synonyms: BBAP, E3 ubiquitin-protein ligase DTX3L, B-lymphoma- and BAL-associated protein, Protein deltex-3-like, Rhysin-2, Rhysin2, DTX3L

    Background: Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.

    ID gène
    151636
    UniProt
    Q8TDB6
    Pathways
    Signalisation Notch
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