Importin 5 anticorps (AA 501-600)

N° du produit ABIN6989196

Détail du produit anti-Importin 5 anticorps

Antigène: Importin 5 (IPO5)

Épitope: AA 501-600

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Importin 5 est non-conjugé

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Réactivité croisée: Rat

Homologie: Human,Mouse,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Karyopherin beta 3

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur Importin 5

Antigène: Importin 5 (IPO5)

Autre désignation: Karyopherin beta 3 (IPO5 Produits)

Synonymes: anticorps IPO5, anticorps RANBP5, anticorps IMB3, anticorps KPNB3, anticorps Pse1, anticorps imp5, anticorps 1110011C18Rik, anticorps 5730478E03Rik, anticorps AA409333, anticorps C76941, anticorps Kpnb3, anticorps Ranbp5, anticorps importin 5, anticorps IPO5, anticorps Ipo5

Sujet:

Synonyms: DKFZp686O1576, FLJ43041, IMB3, Imp5, Importin 5, Importin beta 3 subunit, Importin subunit beta 3, Importin subunit beta-3, Importin-5, IPO 5, IPO5, IPO5_HUMAN, Karyopherin beta 3, Karyopherin beta-3, KPNB3, MGC2068, Pse1, Ran binding protein 5, Ran GTP binding protein 5, Ran-binding protein 5, RanBP 5, RanBP5.

Background: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.

ID gène: 3843

UniProt: O00410

Pathways: Protein targeting to Nucleus