NEK6 anticorps (AA 81-180)

N° du produit ABIN6989319

Détail du produit anti-NEK6 anticorps

Antigène: NEK6 (NIMA (Never in Mitosis Gene A)-Related Kinase 6 (NEK6))

Épitope: AA 81-180

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NEK6 est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Réactivité croisée: Rat

Homologie: Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human NEK6

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur NEK6

Antigène: NEK6 (NIMA (Never in Mitosis Gene A)-Related Kinase 6 (NEK6))

Autre désignation: NEK6 (NEK6 Produits)

Sujet:

Synonyms: Highly similar to cell cycle protein kinase CDC5/MSD2, NEK6, NEK6_HUMAN, Never in mitosis A-related kinase 6, NIMA (Never In Mitosis Gene A) Related Kinase 6, NimA related protein kinase 6, NimA-related protein kinase 6, Protein kinase SID6 1512, Protein kinase SID6-1512, Putative serine threonine protein kinase, Serine/threonine protein kinase Nek6, Serine/threonine-protein kinase Nek6, SID61512.

Background: Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence.

ID gène: 10783

UniProt: Q9HC98