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CHCHD2 anticorps

CHCHD2 Reactivité: Humain, Souris, Rat WB, IF, IF (cc) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6989760
  • Antigène Tous les produits CHCHD2
    CHCHD2 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2 (CHCHD2))
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 20
    Lapin
    Clonalité
    • 20
    Polyclonal
    Conjugué
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp CHCHD2 est non-conjugé
    Application
    • 20
    • 15
    • 15
    • 12
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunofluorescence (Cultured Cells) (IF (cc))
     Réactivité croisée
    Humain, Souris, Rat
    Purification
    Purified by Protein A.
    Immunogène
    Recombinant fusion protein containing a sequence corresponding to amino acids 75-145 of human CHCHD2 (NP_057223.1).
    Isotype
    IgG
  • Indications d'application
    WB 1:300-5000
    IF(ICC) 1:50-200
    IF()
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C for 12 months.
    Date de péremption
    12 months
  • Antigène
    CHCHD2 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2 (CHCHD2))
    Autre désignation
    CHCHD2 (CHCHD2 Produits)
    Synonymes
    anticorps AL033347, anticorps Etohi6, anticorps C7orf17, anticorps CHCHD9, anticorps chchd2, anticorps coiled-coil-helix-coiled-coil-helix domain containing 2, anticorps coiled-coil-helix-coiled-coil-helix domain containing 2 L homeolog, anticorps Chchd2, anticorps CHCHD2, anticorps chchd2.L
    Sujet

    Synonyms: CHCHD2,C7orf17,MNRR1,NS2TP,PARK22

    Background: The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants.

    ID gène
    51142
    UniProt
    Q9Y6H1
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