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SARS-CoV-2 ORF6 anticorps (C-Term)

Reactivité: SARS Coronavirus-2 (SARS-CoV-2) ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6990152
  • Antigène Tous les produits SARS-CoV-2 ORF6
    SARS-CoV-2 ORF6
    Épitope
    C-Term
    Reactivité
    SARS Coronavirus-2 (SARS-CoV-2)
    Hôte
    • 1
    Lapin
    Clonalité
    • 1
    Polyclonal
    Conjugué
    • 1
    Cet anticorp SARS-CoV-2 ORF6 est non-conjugé
    Application
    • 1
    • 1
    ELISA
    Purification
    SARS-CoV-2 (COVID-19) ORF6 Antibody is affinity chromatography purified via peptide column.
    Immunogène
    Anti-SARS-CoV-2 (COVID-19) ORF6 antibody was raised against a peptide corresponding to 15 amino acids near the Carboxyl terminus of SARS-CoV-2 (COVID-19) ORF6 protein. The immunogen is located in the last 50 amino acids of SARS-CoV-2 (COVID-19) ORF6.
    Isotype
    IgG
  • Indications d'application
    Antibody validated: SARS-CoV-2 (COVID-19) ORF6 antibody can detect 2 ng of free peptide at 1 μ,g/mL in ELISA.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    SARS-CoV-2 (COVID-19) ORF6 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,4 °C
    Stockage commentaire
    SARS-CoV-2 (COVID-19) ORF6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Antigène
    SARS-CoV-2 ORF6
    Abstract
    SARS-CoV-2 ORF6 Produits
    Synonymes
    anticorps ORF6 protein, anticorps ORF6
    Classe de substances
    Viral Protein
    Sujet
    Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019-20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. ORF6 disrupts cell nuclear import complex formation by tethering karyopherin alpha 2 and karyopherin beta 1 to the membrane. Retention of import factors at the ER/Golgi membrane leads to a loss of transport into the nucleus. Thereby it prevents STAT1 nuclear translocation in response to interferon signaling, thus blocking the expression of interferon stimulated genes (ISGs) that display multiple antiviral activities(3).
    ID gène
    43740572
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