MPRIP anticorps (C-Term)

N° du produit ABIN6990325

Détail du produit anti-MPRIP anticorps

Antigène: MPRIP (Myosin Phosphatase rho Interacting Protein (MPRIP))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MPRIP est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: RIP3 Antibody is affinity chromatography purified via peptide column.

Immunogène: Anti-RIP3 antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of murine RIP3. The immunogen is located within the last 50 amino acids of RIP3.

Isotype: IgG

Information d'application

Indications d'application: WB: 0.1-0.5 μ,g/mL, IHC-P: 5 μ,g/mL, IF: 20 μ,g/mL, IP: 20 μ,g/mL.

Antibody validated: Western Blot in mouse and human samples, Immunohistochemistry in mouse and rat samples, Immunofluorescence in mouse and rat samples, Immunoprecipitation in human samples, Immunogold EM in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: RIP3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: RIP3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Références pour anticorps anti-MPRIP (ABIN6990325)

Wu, Chung, Cao, Jin, Edmiston, Hickman, Levy, Whalen, Abrams, Degterev, Lo, Tozzi, Kaplan, El Khoury, Whalen: "Genetic inhibition of RIPK3 ameliorates functional outcome in controlled cortical impact independent of necroptosis." dans: Cell death & disease, Vol. 12, Issue 11, pp. 1064, (2021) (PubMed).

Détails sur MPRIP

Antigène: MPRIP (Myosin Phosphatase rho Interacting Protein (MPRIP))

Autre désignation: RIP3 (MPRIP Produits)

Synonymes: anticorps M-RIP, anticorps MRIP, anticorps RHOIP3, anticorps RIP3, anticorps p116Rip, anticorps 9530046C02, anticorps AA536749, anticorps AI647711, anticorps C76423, anticorps Rhoip3, anticorps mKIAA0864, anticorps M-rip, anticorps Mrip, anticorps myosin phosphatase Rho interacting protein, anticorps MPRIP, anticorps Mprip

Sujet: RIP3 Antibody: Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3. RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-κ,B activation. Overexpression of RIP3 induces apoptosis and NF-κ,B activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues.

Poids moléculaire: Predicted: 53kD for mouse RIP3 and 57kD for human RIP3

Observed: 53kD for mouse RIP3 and 57kD for human RIP3 kDa

ID gène: 56532

UniProt: Q9QZL0