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BCL2L13 anticorps (AA 280-330)

BCL2L13 Reactivité: Humain, Souris, Rat WB, ELISA, IF, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6990398
  • Antigène Voir toutes BCL2L13 Anticorps
    BCL2L13 (BCL2-Like 13 (Apoptosis Facilitator) (BCL2L13))
    Épitope
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 280-330
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 17
    • 4
    Lapin
    Clonalité
    • 17
    • 4
    Polyclonal
    Conjugué
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp BCL2L13 est non-conjugé
    Application
    • 13
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    Bcl-rambo Antibody is affinity chromatography purified via peptide column.
    Immunogène
    Bcl-rambo antibody was raised against a 15 amino acid synthetic peptide from near the center of human Bcl-rambo. The immunogen is located within amino acids 280 - 330 of Bcl-rambo.
    Isotype
    IgG
    Top Product
    Discover our top product BCL2L13 Anticorps primaire
  • Indications d'application
    Bcl-rambo antibody can be used for the detection of Bcl-rambo by Western blot at 2 and 4 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Bcl-rambo Antibody is supplied in PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,4 °C
    Stockage commentaire
    Bcl-rambo antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Antigène
    BCL2L13 (BCL2-Like 13 (Apoptosis Facilitator) (BCL2L13))
    Autre désignation
    Bcl-rambo (BCL2L13 Produits)
    Synonymes
    anticorps si:ch211-238n5.7, anticorps Mil1, anticorps BCL-RAMBO, anticorps Bcl2-L-13, anticorps MIL1, anticorps E430016C20Rik, anticorps Mil-1, anticorps BCL2 like 13, anticorps BCL2-like 13 (apoptosis facilitator), anticorps BCL2L13, anticorps bcl2l13, anticorps Bcl2l13
    Sujet
    Bcl-rambo Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A novel, widely expressed member termed Bcl-rambo was recently identified. This protein is localized to mitochondria in mammalian cells and its overexpression induces apoptosis which could be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2. Bcl-rambo shows overall homology to the anti-apoptotic members containing BH motifs, but unlike Bcl-2, the C-terminal membrane anchor of Bcl-rambo is preceded by a unique 250 amino acid insertion. This region by itself can induce apoptosis more efficiently than the Bcl-2 homology regions, suggesting that Bcl-rambo may be important other pro-apoptotic pathways.
    ID gène
    23786
    UniProt
    Q9BXK5
    Pathways
    Positive Regulation of Endopeptidase Activity
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