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BIRC2 anticorps (C-Term)

BIRC2 Reactivité: Humain, Souris, Rat WB, ELISA, IF, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6990458
  • Antigène Voir toutes BIRC2 Anticorps
    BIRC2 (Baculoviral IAP Repeat Containing 2 (BIRC2))
    Épitope
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    AA 540-590, C-Term
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 29
    • 4
    Lapin
    Clonalité
    • 28
    • 5
    Polyclonal
    Conjugué
    • 18
    • 6
    • 5
    • 2
    • 1
    • 1
    Cet anticorp BIRC2 est non-conjugé
    Application
    • 29
    • 17
    • 17
    • 6
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    cIAP Antibody is affinity chromatography purified via peptide column.
    Immunogène
    Anti-cIAP antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human cIAP. c-IAP antibody detects both c-IAP1 and c-IAP2. The immunogen is located within amino acids 540-590 of cIAP.
    Isotype
    IgG
    Top Product
    Discover our top product BIRC2 Anticorps primaire
  • Indications d'application
    WB: 1-4 μ,g/mL, IHC: 10 μ,g/mL, IF: 20 μ,g/mL.

    Antibody validated: Western Blot in human, mouse and rat samples, Immunohistochemistry in human samples, Immunofluorescence in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    cIAP Antibody is supplied in PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,4 °C
    Stockage commentaire
    cIAP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Antigène
    BIRC2 (Baculoviral IAP Repeat Containing 2 (BIRC2))
    Autre désignation
    cIAP (BIRC2 Produits)
    Sujet
    CIAP Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. The two isoforms of c-IAP (c-IAP1 and c-IAP2) are structurally related to XIAP, containing 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases-3, -7. The c-IAPs can associate with the death receptor TNF-R2, and mediate the ubiquitinization of TRAF2 following the binding of TNF-α, by its receptor. Omi, a negative regulator of c-IAP, inhibits its activity by catalytically cleaving c-IAP. Another negative regulator, Smac/DIABLO, acts by enhancing the auto-ubiquitization activity of c-IAP.
    Poids moléculaire
    Predicted: 70kD

    Observed: 70kD kDa
    ID gène
    329
    NCBI Accession
    NP_001157
    UniProt
    Q13490
    Pathways
    Apoptose, Caspase Cascade in Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades
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