SIGIRR anticorps (C-Term)

N° du produit ABIN6990481

Détail du produit anti-SIGIRR anticorps

Antigène: SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIGIRR est non-conjugé

Application: Western Blotting (WB), Immunocytochemistry (ICC), ELISA

Purification: SIGIRR Antibody is affinity chromatography purified via peptide column.

Immunogène: SIGIRR antibody was raised against a synthetic peptide corresponding to 15 amino acids at the C-terminus of human SIGIRR. The immunogen is located within the last 50 amino acids of SIGIRR.

Isotype: IgG

Information d'application

Indications d'application: SIGIRR antibody can be used for the detection of SIGIRR by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: SIGIRR Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: SIGIRR antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur SIGIRR

Antigène: SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))

Autre désignation: SIGIRR (SIGIRR Produits)

Synonymes: anticorps TIR8, anticorps AI256711, anticorps sc:d148, anticorps RGD1306732, anticorps single Ig and TIR domain containing, anticorps single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, anticorps SIGIRR, anticorps Sigirr, anticorps sigirr

Sujet: SIGIRR Antibody: SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily. Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain. The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family. Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling. However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R. It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion.

Poids moléculaire: Predicted: 45 kDa

Observed: 45 kDa 

ID gène: 59307

UniProt: Q6IA17

Pathways: Toll-Like Receptors Cascades