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SIGIRR anticorps (C-Term)

SIGIRR Reactivité: Humain, Souris WB, ICC, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6990481
  • Antigène Voir toutes SIGIRR Anticorps
    SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
    Épitope
    • 8
    • 6
    • 3
    • 2
    • 2
    • 2
    C-Term
    Reactivité
    • 21
    • 11
    • 8
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris
    Hôte
    • 24
    • 4
    • 1
    Lapin
    Clonalité
    • 24
    • 5
    Polyclonal
    Conjugué
    • 21
    • 6
    • 2
    Cet anticorp SIGIRR est non-conjugé
    Application
    • 27
    • 14
    • 9
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunocytochemistry (ICC), ELISA
    Purification
    SIGIRR Antibody is affinity chromatography purified via peptide column.
    Immunogène
    SIGIRR antibody was raised against a synthetic peptide corresponding to 15 amino acids at the C-terminus of human SIGIRR. The immunogen is located within the last 50 amino acids of SIGIRR.
    Isotype
    IgG
    Top Product
    Discover our top product SIGIRR Anticorps primaire
  • Indications d'application
    SIGIRR antibody can be used for the detection of SIGIRR by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL.

    Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    SIGIRR Antibody is supplied in PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,4 °C
    Stockage commentaire
    SIGIRR antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Antigène
    SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
    Autre désignation
    SIGIRR (SIGIRR Produits)
    Synonymes
    anticorps TIR8, anticorps AI256711, anticorps sc:d148, anticorps RGD1306732, anticorps single Ig and TIR domain containing, anticorps single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, anticorps SIGIRR, anticorps Sigirr, anticorps sigirr
    Sujet
    SIGIRR Antibody: SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily. Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain. The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family. Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling. However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R. It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion.
    Poids moléculaire
    Predicted: 45 kDa

    Observed: 45 kDa 
    ID gène
    59307
    UniProt
    Q6IA17
    Pathways
    Toll-Like Receptors Cascades
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