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TAB2 anticorps (C-Term)

TAB2 Reactivité: Humain ELISA, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6990488
  • Antigène Voir toutes TAB2 Anticorps
    TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))
    Épitope
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    C-Term
    Reactivité
    • 17
    • 8
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 15
    • 4
    Lapin
    Clonalité
    • 17
    • 2
    Polyclonal
    Conjugué
    • 19
    Cet anticorp TAB2 est non-conjugé
    Application
    • 15
    • 7
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    TAB2 antibody is human specific. TAB2 antibody is predicted not to cross-react with other TAB proteins.
    Purification
    TAB2 Antibody is affinity chromatography purified via peptide column.
    Immunogène
    TAB2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human TAB2. The immunogen is located within the last 50 amino acids of TAB2.
    Isotype
    IgG
    Top Product
    Discover our top product TAB2 Anticorps primaire
  • Indications d'application
    TAB2 antibody can be used for detection of TAB2 by immunohistochemistry at 5 μ,g/mL.

    Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    TAB2 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,4 °C
    Stockage commentaire
    TAB2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Antigène
    TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))
    Autre désignation
    TAB2 (TAB2 Produits)
    Synonymes
    anticorps CHTD2, anticorps MAP3K7IP2, anticorps 1110030N06Rik, anticorps A530078N03Rik, anticorps Map3k7ip2, anticorps mKIAA0733, anticorps map3k7ip2, anticorps zgc:77446, anticorps TGF-beta activated kinase 1/MAP3K7 binding protein 2, anticorps TAB2, anticorps Tab2, anticorps tab2
    Sujet
    TAB2 Antibody: TAB2 is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation NF-kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1, upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
    ID gène
    23118
    NCBI Accession
    NP_055908
    UniProt
    Q9NYJ8
    Pathways
    TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway
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