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PTRH2 anticorps (AA 80-130)

PTRH2 Reactivité: Humain, Souris WB, ELISA, IF, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6990570
  • Antigène Voir toutes PTRH2 Anticorps
    PTRH2 (Peptidyl-tRNA Hydrolase 2 (PTRH2))
    Épitope
    • 13
    • 11
    • 11
    • 6
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 80-130
    Reactivité
    • 60
    • 14
    • 14
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 59
    • 1
    Lapin
    Clonalité
    • 60
    Polyclonal
    Conjugué
    • 22
    • 6
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp PTRH2 est non-conjugé
    Application
    • 41
    • 26
    • 19
    • 9
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    Bit1 Antibody is affinity chromatography purified via peptide column.
    Immunogène
    Bit1 antibody was raised against a 16 amino acid synthetic peptide from near the center of human Bit1. The immunogen is located within amino acids 80 - 130 of Bit1.
    Isotype
    IgG
    Top Product
    Discover our top product PTRH2 Anticorps primaire
  • Indications d'application
    Bit1 antibody can be used for the detection of Bit1 by Western blot at 1 - 4 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Bit1 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,4 °C
    Stockage commentaire
    Bit1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Antigène
    PTRH2 (Peptidyl-tRNA Hydrolase 2 (PTRH2))
    Autre désignation
    Bit1 (PTRH2 Produits)
    Synonymes
    anticorps BIT1, anticorps PTH2, anticorps A230072I16Rik, anticorps Bit1, anticorps CGI-147, anticorps wu:fj09f02, anticorps zgc:109954, anticorps RGD1306819, anticorps peptidyl-tRNA hydrolase 2, anticorps ptrh2, anticorps CC1G_10259, anticorps ANI_1_1036184, anticorps AOR_1_2082154, anticorps PTRH2, anticorps Ptrh2
    Sujet
    Bit1 Antibody: Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment. Bit1 (Bcl-2 inhibitor of transcription 1) was recently identified as being involved in this process. Bit1 is a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis where it forms a complex with AES, a small Groucho/transducin-like enhancer of split (TLE) protein and induces caspase-independent apoptosis. Both AES and TLE proteins are transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. It has been suggested that Bit1-AES complexes turn off a survival-promoting gene transcription program controlled by TLE. Interestingly, apoptosis of cells transfected with Bit1 and AES could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin.
    ID gène
    51651
    NCBI Accession
    NP_057161
    UniProt
    Q9Y3E5
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