DRAM anticorps (N-Term)

N° du produit ABIN6990614

Détail du produit anti-DRAM anticorps

Antigène: DRAM (DRAM1) (DNA-Damage Regulated Autophagy Modulator 1 (DRAM1))

Épitope: AA 30-80, N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DRAM est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Purification: DRAM Antibody is affinity chromatography purified via peptide column.

Immunogène: Anti-DRAM antibody was raised against a peptide corresponding to 16 amino acids near the amino terminus of human DRAM. The immunogen is located within amino acids 30-80 of DRAM.

Isotype: IgG

Information d'application

Indications d'application: WB: 1-2 μ,g/mL, IF: 20 μ,g/mL, IHC: 2-2.5 μ,g/mL.

Antibody validated: Western Blot in human mouse and rat samples, Immunofluorescence and Immunohistochemistry in human and mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: DRAM Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: DRAM antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur DRAM

Antigène: DRAM (DRAM1) (DNA-Damage Regulated Autophagy Modulator 1 (DRAM1))

Autre désignation: DRAM (DRAM1 Produits)

Synonymes: anticorps DRAM1, anticorps DRAM, anticorps 1200002N14Rik, anticorps Dram, anticorps dram, anticorps DNA damage regulated autophagy modulator 1, anticorps DNA-damage regulated autophagy modulator 1, anticorps DNA damage regulated autophagy modulator 1 L homeolog, anticorps DRAM1, anticorps Dram1, anticorps dram1.L

Sujet: DRAM Antibody: Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes together promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.

Poids moléculaire: Predicted: 14kD, 26kD

Observed: 14 kD, 26kD kDa

ID gène: 55332

UniProt: Q8N682