NPAS3 anticorps (AA 470-520)

N° du produit ABIN6990741

Détail du produit anti-NPAS3 anticorps

Antigène: NPAS3 (Neuronal PAS Domain Protein 3 (NPAS3))

Épitope: AA 470-520

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NPAS3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Purification: NPAS3 Antibody is affinity chromatography purified via peptide column.

Immunogène: NPAS3 antibody was raised against a 28 amino acid synthetic peptide from near the center of human NPAS3. The immunogen is located within amino acids 470 - 520 of NPAS3.

Isotype: IgG

Information d'application

Indications d'application: NPAS3 antibody can be used for detection of NPAS3 by Western blot at 0.5 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: NPAS3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: NPAS3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur NPAS3

Antigène: NPAS3 (Neuronal PAS Domain Protein 3 (NPAS3))

Autre désignation: NPAS3 (NPAS3 Produits)

Synonymes: anticorps trh, anticorps mop6, anticorps pasd6, anticorps MGC145768, anticorps MOP6, anticorps PASD6, anticorps bHLHe12, anticorps 4930423H22Rik, anticorps neuronal PAS domain protein 3, anticorps npas3, anticorps NPAS3, anticorps Npas3

Sujet: NPAS3 Antibody: Neuronal PAS domain protein 3 (NPAS3) is a brain-enriched basic helix-loop-helix PAS domain transcription factor and is broadly expressed in the developing neuroepithelium and has recently found to be disrupted by genetic translocation in a family affected with schizophrenia. It was recently shown to be involved in the regulation of FGF signaling in the dentate gyrus by controlling the expression of the FGF receptor subtype 1 and in turn neurogenesis emanating from this region. NPAS3-null mice were growth-retarded and displayed brain defects that included reduced size of the anterior hippocampus, hypoplasia of the corpus callosum, and enlargement of the ventricles, as well as several behavioral abnormalities. Furthermore, these NPAS3-null mice also exhibited disruptions in several neurosignaling pathways involving glutamate, dopamine, and serotonin. These results demonstrate the essential role played by NPAS3 during structural and functional brain development. At least three isoforms of NPAS3 are known to exist.

ID gène: 64067

UniProt: Q8IXF0