MANF anticorps (C-Term)

N° du produit ABIN6990751

Détail du produit anti-MANF anticorps

Antigène: MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MANF est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody does not cross-react with CDNF. The specificity of this antibody was further verified by MANF specific knockout. MANF signal was not detected in MANF knockout HEK293T cells as compared to that in control wild type cells.

Purification: MANF Antibody is affinity chromatography purified via peptide column.

Classe de qualité: KO Validated

Immunogène: MANF antibody was raised against a 12 amino acid synthetic peptide from near the carboxy terminus of human MANF. The immunogen is located within the last 50 amino acids of MANF.

Isotype: IgG

Information d'application

Indications d'application: WB: 0.125-2 μ,g/mL, IHC: 2.5 μ,g/mL, IF: 20 μ,g/mL

Antibody validated: Western Blot in human, mouse and rat samples, Immunohistochemistry in human samples, Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: MANF Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: MANF antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur MANF

Antigène: MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))

Autre désignation: MANF (MANF Produits)

Synonymes: anticorps ARMET, anticorps ARP, anticorps 3230402M22Rik, anticorps AA407711, anticorps AA408789, anticorps AA673178, anticorps Armet, anticorps D17914, anticorps D18Mgi17, anticorps MANF, anticorps RBM15B, anticorps ARP-like, anticorps CG7013, anticorps DmMANF, anticorps Dmel\\CG7013, anticorps anon-EST:ParkEST188, anticorps arp, anticorps armet, anticorps im:6909481, anticorps zgc:153327, anticorps manf, anticorps mesencephalic astrocyte derived neurotrophic factor, anticorps mesencephalic astrocyte-derived neurotrophic factor, anticorps RNA binding motif protein 15B, anticorps Mesencephalic astrocyte-derived neurotrophic factor, anticorps mesencephalic astrocyte-derived neurotrophic factor S homeolog, anticorps MANF, anticorps Manf, anticorps RBM15B, anticorps manf, anticorps manf.S

Sujet: MANF Antibody: MANF, also known as ARMET, was initially identified as a protein containing an arginine-rich region that was highly mutated in a variety of tumors. More recently it was identified as a mesencephalic astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons, similar to glial cell line-derived neurotrophic factor (GDNF) and CDNF. In rat brain slices, MANF enhanced nigral gamma-aminobutyric acid release. Like GDNF and CDNF, MANF has selective neuroprotective activity for dopaminergic neurons suggesting that it may be indicated for the treatment of Parkinson's disease. Expression of MANF has also been shown to be induced during ER stress, suggesting that it may play a role in protein quality control during ER stress.

Poids moléculaire: Predicted: 20kD

Observed: 18 kD kDa

ID gène: 7873

UniProt: P55145