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MANF anticorps (C-Term)

KO Validated MANF Reactivité: Humain, Souris, Rat WB, ELISA, IF, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6990751
  • Antigène Voir toutes MANF Anticorps
    MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))
    Épitope
    • 8
    • 7
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 47
    • 20
    • 18
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 38
    • 8
    • 1
    Lapin
    Clonalité
    • 41
    • 6
    Polyclonal
    Conjugué
    • 28
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MANF est non-conjugé
    Application
    • 39
    • 23
    • 10
    • 6
    • 6
    • 4
    • 4
    • 3
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    This antibody does not cross-react with CDNF. The specificity of this antibody was further verified by MANF specific knockout. MANF signal was not detected in MANF knockout HEK293T cells as compared to that in control wild type cells.
    Purification
    MANF Antibody is affinity chromatography purified via peptide column.
    Classe de qualité
    KO Validated
    Immunogène
    MANF antibody was raised against a 12 amino acid synthetic peptide from near the carboxy terminus of human MANF. The immunogen is located within the last 50 amino acids of MANF.
    Isotype
    IgG
    Top Product
    Discover our top product MANF Anticorps primaire
  • Indications d'application
    WB: 0.125-2 μ,g/mL, IHC: 2.5 μ,g/mL, IF: 20 μ,g/mL

    Antibody validated: Western Blot in human, mouse and rat samples, Immunohistochemistry in human samples, Immunofluorescence in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    MANF Antibody is supplied in PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,4 °C
    Stockage commentaire
    MANF antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Antigène
    MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))
    Autre désignation
    MANF (MANF Produits)
    Synonymes
    anticorps ARMET, anticorps ARP, anticorps 3230402M22Rik, anticorps AA407711, anticorps AA408789, anticorps AA673178, anticorps Armet, anticorps D17914, anticorps D18Mgi17, anticorps MANF, anticorps RBM15B, anticorps ARP-like, anticorps CG7013, anticorps DmMANF, anticorps Dmel\\CG7013, anticorps anon-EST:ParkEST188, anticorps arp, anticorps armet, anticorps im:6909481, anticorps zgc:153327, anticorps manf, anticorps mesencephalic astrocyte derived neurotrophic factor, anticorps mesencephalic astrocyte-derived neurotrophic factor, anticorps RNA binding motif protein 15B, anticorps Mesencephalic astrocyte-derived neurotrophic factor, anticorps mesencephalic astrocyte-derived neurotrophic factor S homeolog, anticorps MANF, anticorps Manf, anticorps RBM15B, anticorps manf, anticorps manf.S
    Sujet
    MANF Antibody: MANF, also known as ARMET, was initially identified as a protein containing an arginine-rich region that was highly mutated in a variety of tumors. More recently it was identified as a mesencephalic astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons, similar to glial cell line-derived neurotrophic factor (GDNF) and CDNF. In rat brain slices, MANF enhanced nigral gamma-aminobutyric acid release. Like GDNF and CDNF, MANF has selective neuroprotective activity for dopaminergic neurons suggesting that it may be indicated for the treatment of Parkinson's disease. Expression of MANF has also been shown to be induced during ER stress, suggesting that it may play a role in protein quality control during ER stress.
    Poids moléculaire
    Predicted: 20kD

    Observed: 18 kD kDa
    ID gène
    7873
    UniProt
    P55145
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