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SP110 anticorps (C-Term)

SP110 Reactivité: Humain, Souris, Rat WB, ELISA, IHC (p), IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6990830
  • Antigène Voir toutes SP110 Anticorps
    SP110 (SP110 Nuclear Body Protein (SP110))
    Épitope
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 470-520, C-Term
    Reactivité
    • 21
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 15
    • 6
    Lapin
    Clonalité
    • 18
    • 3
    Polyclonal
    Conjugué
    • 18
    • 1
    • 1
    • 1
    Cet anticorp SP110 est non-conjugé
    Application
    • 18
    • 8
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Purification
    IPR1 Antibody is affinity chromatography purified via peptide column.
    Immunogène
    IPR1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of the human IPR1. The immunogen is located within amino acids 470 - 520 of IPR1.
    Isotype
    IgG
    Top Product
    Discover our top product SP110 Anticorps primaire
  • Indications d'application
    Ipr1 antibody can be used for detection of Ipr1 by Western blot at 0.5 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    IPR1 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,4 °C
    Stockage commentaire
    IPR1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Antigène
    SP110 (SP110 Nuclear Body Protein (SP110))
    Autre désignation
    IPR1 (SP110 Produits)
    Synonymes
    anticorps SP110, anticorps IFI41, anticorps IFI75, anticorps IPR1, anticorps VODI, anticorps 5031415C07Rik, anticorps 52kDa, anticorps 5830484A20Rik, anticorps ENSMUSG00000075603, anticorps Ifi75, anticorps Ipr1, anticorps SP110 nuclear body protein, anticorps Sp110 nuclear body protein, anticorps SP110, anticorps Sp110
    Sujet
    IPR1 Antibody: Susceptibility to tuberculosis (TB) in mice has recently been attributed to the IPR1 gene. IPR1 is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. SP110 is the closest homolog of the IPR1 protein in humans. The IPR1/Sp110 gene product might play a role in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death, and pathogenesis. IPR1/Sp110 is up-regulated after infection with M. tuberculosis and required by Anaplasma phagocytophilum for infection of human promyelocytic cells. Defects in Sp110 are a cause of severely impaired resistance to infection by M. tuberculosis.
    ID gène
    3431
    NCBI Accession
    NP_004501
    UniProt
    Q9HB58
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