SP110 anticorps (N-Term)

N° du produit ABIN6990831

Détail du produit anti-SP110 anticorps

Antigène: SP110 (SP110 Nuclear Body Protein (SP110))

Épitope: AA 70-120, N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SP110 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: IPR1 Antibody is affinity chromatography purified via peptide column.

Immunogène: IPR1 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of the human IPR1. The immunogen is located within amino acids 70 - 120 of IPR1.

Isotype: IgG

Information d'application

Indications d'application: Ipr1 antibody can be used for detection of Ipr1 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: IPR1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: IPR1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur SP110

Antigène: SP110 (SP110 Nuclear Body Protein (SP110))

Autre désignation: IPR1 (SP110 Produits)

Synonymes: anticorps SP110, anticorps IFI41, anticorps IFI75, anticorps IPR1, anticorps VODI, anticorps 5031415C07Rik, anticorps 52kDa, anticorps 5830484A20Rik, anticorps ENSMUSG00000075603, anticorps Ifi75, anticorps Ipr1, anticorps SP110 nuclear body protein, anticorps Sp110 nuclear body protein, anticorps SP110, anticorps Sp110

Sujet: IPR1 Antibody: Susceptibility to tuberculosis (TB) in mice has recently been attributed to the IPR1 gene. IPR1 is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. SP110 is the closest homolog of the IPR1 protein in humans. The IPR1/Sp110 gene product might play a role in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death, and pathogenesis. IPR1/Sp110 is up-regulated after infection with M. tuberculosis and required by Anaplasma phagocytophilum for infection of human promyelocytic cells. Defects in Sp110 are a cause of severely impaired resistance to infection by M. tuberculosis.

ID gène: 3431

NCBI Accession: NP_004501

UniProt: Q9HB58