Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

ASAH2 anticorps (C-Term)

ASAH2 Reactivité: Humain, Souris, Rat WB, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6990954
  • Antigène Voir toutes ASAH2 Anticorps
    ASAH2 (N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2 (ASAH2))
    Épitope
    • 8
    • 8
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 33
    • 1
    Lapin
    Clonalité
    • 34
    Polyclonal
    Conjugué
    • 11
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ASAH2 est non-conjugé
    Application
    • 20
    • 19
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Purification
    ASAH2 Antibody is affinity chromatography purified via peptide column.
    Immunogène
    ASAH2 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human ASAH2. The immunogen is located within the last 50 amino acids of ASAH2.
    Isotype
    IgG
    Top Product
    Discover our top product ASAH2 Anticorps primaire
  • Indications d'application
    ASAH2 antibody can be used for detection of ASAH2 by Western blot at 1 and 2 μ,g/mL.

    Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    ASAH2 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,4 °C
    Stockage commentaire
    ASAH2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Antigène
    ASAH2 (N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2 (ASAH2))
    Autre désignation
    ASAH2 (ASAH2 Produits)
    Synonymes
    anticorps BCDase, anticorps HNAC1, anticorps LCDase, anticorps N-CDase, anticorps NCDase, anticorps AI585898, anticorps N-acylsphingosine amidohydrolase 2, anticorps ASAH2, anticorps Asah2
    Sujet
    ASAH2 Antibody: Sphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids. These ceramidases are classified according to the pH range that supports their optimal activity. ASAH2 is a neutral ceramidase and key regulator of sphingolipid signaling metabolites at the cell surface, catalyzing the hydrolysis of the N-acyl linkage of ceramide at an optimal pH of 6.5-8.5. ASAH2 is a type II integral membrane protein that can be cleaved to yield a soluble secreted protein and acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger. ASAH2 is ubiquitously expressed primarily expressed with higher levels in the intestine, kidney, skeletal muscle and heart. Recent studies indicate that ASAH2 encoded neutral ceramidase is a key enzyme for the catabolism of dietary sphingolipids and regulates the levels of bioactive sphingolipid metabolites in the intestinal tract.
    ID gène
    56624
    NCBI Accession
    NP_063946
    UniProt
    Q9NR71
Vous êtes ici:
Support technique