SPRED1 anticorps (AA 250-300)

N° du produit ABIN6990996

Détail du produit anti-SPRED1 anticorps

Antigène: SPRED1 (Sprouty-Related, EVH1 Domain Containing 1 (SPRED1))

Épitope: AA 250-300

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPRED1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificité: This Spred1 antibody is predicted to have no cross-reactivity to Spred2 or Spred3.

Purification: Spred1 Antibody is affinity chromatography purified via peptide column.

Immunogène: Spred1 antibody was raised against a 14 amino acid synthetic peptide near the center of the human Spred1. The immunogen is located within amino acids 250 - 300 of Spred1.

Isotype: IgG

Information d'application

Indications d'application: Spred1 antibody can be used for detection of Spred1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Spred1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: Spred1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur SPRED1

Antigène: SPRED1 (Sprouty-Related, EVH1 Domain Containing 1 (SPRED1))

Autre désignation: Spred1 (SPRED1 Produits)

Synonymes: anticorps fb14c08, anticorps fj51c03, anticorps zgc:85707, anticorps wu:fb14c08, anticorps wu:fj51c03, anticorps Xspred1, anticorps Xtspred1, anticorps 5730461F13Rik, anticorps AL024345, anticorps AW047647, anticorps NFLS, anticorps hSpred1, anticorps spred-1, anticorps sprouty-related, EVH1 domain containing 1, anticorps sprouty related EVH1 domain containing 1, anticorps sprouty related, EVH1 domain containing 1, anticorps sprouty related, EVH1 domain containing 1 L homeolog, anticorps SPRED1, anticorps sprouty protein with EVH-1 domain 1, related sequence, anticorps spred1, anticorps SPRED1, anticorps spred1.L, anticorps Bm1_51610, anticorps Spred1

Sujet: Spred1 Antibody: The Ras-MAP kinase pathway is essential for the differentiation of neuronal cells and myocytes, it is inhibited by Spred1, a member of the Sprouty family of proteins. Spred1 acts by suppressing the phosphorylation and activation of Raf. The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis. Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS).

Poids moléculaire: Predicted: 49 kDa

Observed: 498 kDa

ID gène: 161742

NCBI Accession: NP_689807

UniProt: Q7Z699

Pathways: Positive Regulation of Response to DNA Damage Stimulus