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SPRED1 anticorps (AA 250-300)

SPRED1 Reactivité: Humain, Souris, Rat WB, ELISA, IHC (p), IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6990996
  • Antigène Voir toutes SPRED1 Anticorps
    SPRED1 (Sprouty-Related, EVH1 Domain Containing 1 (SPRED1))
    Épitope
    • 7
    • 7
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 250-300
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 37
    • 7
    Lapin
    Clonalité
    • 37
    • 7
    Polyclonal
    Conjugué
    • 20
    • 6
    • 5
    • 5
    • 4
    • 4
    Cet anticorp SPRED1 est non-conjugé
    Application
    • 39
    • 33
    • 20
    • 7
    • 6
    • 3
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Specificité
    This Spred1 antibody is predicted to have no cross-reactivity to Spred2 or Spred3.
    Purification
    Spred1 Antibody is affinity chromatography purified via peptide column.
    Immunogène
    Spred1 antibody was raised against a 14 amino acid synthetic peptide near the center of the human Spred1. The immunogen is located within amino acids 250 - 300 of Spred1.
    Isotype
    IgG
    Top Product
    Discover our top product SPRED1 Anticorps primaire
  • Indications d'application
    Spred1 antibody can be used for detection of Spred1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Spred1 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,4 °C
    Stockage commentaire
    Spred1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Antigène
    SPRED1 (Sprouty-Related, EVH1 Domain Containing 1 (SPRED1))
    Autre désignation
    Spred1 (SPRED1 Produits)
    Synonymes
    anticorps fb14c08, anticorps fj51c03, anticorps zgc:85707, anticorps wu:fb14c08, anticorps wu:fj51c03, anticorps Xspred1, anticorps Xtspred1, anticorps 5730461F13Rik, anticorps AL024345, anticorps AW047647, anticorps NFLS, anticorps hSpred1, anticorps spred-1, anticorps sprouty-related, EVH1 domain containing 1, anticorps sprouty related EVH1 domain containing 1, anticorps sprouty related, EVH1 domain containing 1, anticorps sprouty related, EVH1 domain containing 1 L homeolog, anticorps SPRED1, anticorps sprouty protein with EVH-1 domain 1, related sequence, anticorps spred1, anticorps SPRED1, anticorps spred1.L, anticorps Bm1_51610, anticorps Spred1
    Sujet
    Spred1 Antibody: The Ras-MAP kinase pathway is essential for the differentiation of neuronal cells and myocytes, it is inhibited by Spred1, a member of the Sprouty family of proteins. Spred1 acts by suppressing the phosphorylation and activation of Raf. The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis. Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS).
    Poids moléculaire
    Predicted: 49 kDa

    Observed: 498 kDa
    ID gène
    161742
    NCBI Accession
    NP_689807
    UniProt
    Q7Z699
    Pathways
    Positive Regulation of Response to DNA Damage Stimulus
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