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TTBK1 anticorps (C-Term)

Ttbk1 Reactivité: Humain, Souris WB, ELISA, IHC (p), IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6991059
  • Antigène Voir toutes TTBK1 (Ttbk1) Anticorps
    TTBK1 (Ttbk1) (tau Tubulin Kinase 1 (Ttbk1))
    Épitope
    • 8
    • 7
    • 7
    • 6
    • 1
    AA 1190-1240, C-Term
    Reactivité
    Humain, Souris
    Hôte
    • 29
    Lapin
    Clonalité
    • 29
    Polyclonal
    Conjugué
    • 7
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TTBK1 est non-conjugé
    Application
    • 22
    • 18
    • 13
    • 3
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Specificité
    Multiple isoforms of TTBK1 are known to exist. This antibody is predicted to not cross-react with TTBK2.
    Purification
    TTBK1 Antibody is affinity chromatography purified via peptide column.
    Immunogène
    TTBK1 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human TTBK1. The immunogen is located within amino acids 1190 - 1240 of TTBK1.
    Isotype
    IgG
    Top Product
    Discover our top product Ttbk1 Anticorps primaire
  • Indications d'application
    TTBK1 antibody can be used for detection of TTBK1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    TTBK1 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,4 °C
    Stockage commentaire
    TTBK1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Antigène
    TTBK1 (Ttbk1) (tau Tubulin Kinase 1 (Ttbk1))
    Autre désignation
    TTBK1 (Ttbk1 Produits)
    Synonymes
    anticorps BDTK, anticorps AU017937, anticorps AW048023, anticorps C330008L01Rik, anticorps RGD1559518, anticorps tau tubulin kinase 1, anticorps TTBK1, anticorps Ttbk1
    Sujet
    TTBK1 Antibody: Tau tubulin kinase (TTBK1) belongs to the casein kinase 1 superfamily and is involved in the phosphorylation of specific serine/threonine residues in paired helical filaments of the tau protein. It is specifically expressed in the brain and induces tau aggregation in human neuronal cells in a dose-dependent manner. TTBK1 levels have been found to be upregulated in the brains of Alzheimer's disease (AD) patients, and mice expressing human TTBK1 protein showed significant age-dependent memory impairment. These mice displayed increased levels of the CDK5 activators p25 and p35, and reduced levels of the NMDA receptor types 2B and 2D, suggesting that TTBK1 may play a role in memory dysfunction in AD patients.
    Poids moléculaire
    Predicted: 145, 151 kDa

    Observed: 140 kDa
    ID gène
    84630
    UniProt
    Q5TCY1
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